呋喃并[2,3-b]吡啶-5-基甲醇合成路线 （共 4 条）
反应条件
diisobutylaluminium hydride in tetrahydrofuran T=-4°C;
参考文献
Bhupathy; Conlon; Wells; Nelson; Reider; Rossen; Sager; Volante; Dorsey; Hoffman Jr.; Joseph; McDaniel
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 4 p. 1283 - 1287
反应条件
1: LiOH*H2O / tetrahydrofuran / Ambient temperature; overnight 2: 86 percent / ammonium formate / 2.) 5percent Pd on C / tetrahydrofuran; H2O / 6 h / Ambient temperature 3: 59 percent / Cu2O / quinoline / 2 h / 150 °C 4: 78 percent / DIBAL-H / tetrahydrofuran / -4 °C View Scheme
参考文献
Bhupathy; Conlon; Wells; Nelson; Reider; Rossen; Sager; Volante; Dorsey; Hoffman Jr.; Joseph; McDaniel
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 4 p. 1283 - 1287
反应条件
in water; dimethyl sulfoxide
参考文献
Merck and Co., Inc.
Patent: US5705515 A1, 1998 ;
US 5705515 A
反应条件
Dess-Martin periodane in dichloromethane
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2008/132679 A1, 2008 ;
Location in patent: Page/Page column 88 ;
WO 2008/132679 A1
