9-苄基-2,3,4,9-四氢-1H-咔唑合成路线 （共 28 条）
反应条件
methyllithium in tetrahydrofuran -40 deg C, 1 h; r.t., overnight;
参考文献
Tetrahedron Letters, , vol. 36, # 10 p. 1671 - 1672
反应条件
caesium carbonate; bis[2-(diphenylphosphino)phenyl] ether; tris(dibenzylideneacetone)dipalladium (0) in toluene
T=100°C; 24 h;
参考文献
Willis, Michael C.; Brace, Gareth N.; Holmes, Ian P.
Angewandte Chemie - International Edition, 2005 , vol. 44, # 3 p. 403 - 406
反应条件
1.1: 78 percent / xantphos; cesium carbonate / Pd2(dba)3 / dioxane / 24 h / 80 °C
2.1: sodium hydride / dimethylformamide / 3 h / 0 °C
2.2: 87 percent / dimethylformamide / 20 °C
3.1: 70 percent / dpephos; cesium carbonate / Pd2(dba)3 / toluene / 24 h / 100 °C
View Scheme
参考文献
Willis, Michael C.; Brace, Gareth N.; Holmes, Ian P.
Angewandte Chemie - International Edition, 2005 , vol. 44, # 3 p. 403 - 406
反应条件
ammonium formate; palladium on activated charcoal in methanol
2 h; Heating;
参考文献
Kiguchi, Toshiko; Kuninobu, Naoko; Takahashi, Yoshiko; Yoshida, Yukiyo; Naito, Takeaki; Ninomiya, Ichiya
Synthesis, 1989 , # 10 p. 778 - 781
反应条件
1.1: sodium hydride / dimethylformamide / 3 h / 0 °C
1.2: 87 percent / dimethylformamide / 20 °C
2.1: 70 percent / dpephos; cesium carbonate / Pd2(dba)3 / toluene / 24 h / 100 °C
View Scheme
参考文献
Willis, Michael C.; Brace, Gareth N.; Holmes, Ian P.
Angewandte Chemie - International Edition, 2005 , vol. 44, # 3 p. 403 - 406
反应条件
1.1: 78 percent / xantphos; cesium carbonate / Pd2(dba)3 / dioxane / 24 h / 80 °C
2.1: sodium hydride / dimethylformamide / 3 h / 0 °C
2.2: 87 percent / dimethylformamide / 20 °C
3.1: 70 percent / dpephos; cesium carbonate / Pd2(dba)3 / toluene / 24 h / 100 °C
View Scheme
参考文献
Willis, Michael C.; Brace, Gareth N.; Holmes, Ian P.
Angewandte Chemie - International Edition, 2005 , vol. 44, # 3 p. 403 - 406
反应条件
1: With copper(l) iodide; potassium carbonate; N,N-dimethylethylenediamine in toluene
T=110°C; Fischer Indole Synthesis; 24 h; Schlenk techniqueInert atmosphere;
2: With zinc(II) chloride in toluene
T=90°C; Fischer Indole Synthesis; 1 h;
参考文献
Zhan, Fuxu; Liang, Guangxin
Angewandte Chemie - International Edition, 2013 , vol. 52, # 4 p. 1266 - 1269
Angew. Chem., 2012 , vol. 125, # 4 p. 1304 - 1307,4
反应条件
1.1: AlEt3 / CH2Cl2 / 0.5 h / 0 °C
1.2: 86 percent / CH2Cl2 / 24 h / 20 °C
2.1: 87 percent / DMSO / CH2Cl2 / 1 h / -78 °C
3.1: Pd(PPh3)4 / benzene / 20 °C
4.1: TFA
View Scheme
参考文献
Sole, Daniel; Vallverdu, Lluis; Solans, Xavier; Font-Bardia, Merce; Bonjoch, Josep
Journal of the American Chemical Society, 2003 , vol. 125, # 6 p. 1587 - 1594
反应条件
potassium hydroxide in dimethyl sulfoxide
2.5 h; Ambient temperature;
参考文献
Yokoyama, Yuusaku; Okuyama, Naomi; Iwadate, Shinji; Momoi, Tokuko; Murakami, Yasuoki
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 5 p. 1319 - 1329
反应条件
potassium hydroxide; acetone
参考文献
Kotschetkow et al.
Zhurnal Obshchei Khimii, 1956 , vol. 26, p. 3144,3147; engl. Ausg. S. 3505, 3507
