2-羟甲基吡咯烷-1-羧酸丁酯合成路线 （共 14 条）
参考文献
E. R. Squibb and Sons, Inc.
Patent: US4902684 A1, 1990 ;
反应条件
1: oxalyl chloride; DMSO; Et3N / CH2Cl2 2: CH2Cl2 / 20 °C 3: H2 / Pd/C / methanol 4: HCl View Scheme
参考文献
Shankaran; Donnelly, Karla L.; Shah, Shrenik K.; Guthikonda, Ravindra N.; MacCoss, Malcolm; Humes, John L.; Pacholok, Stephen G.; Grant, Stephan K.; Kelly; Wong
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 17 p. 4539 - 4544
反应条件
triphenylphosphine in 1,2-dichloromethane; toluene
参考文献
Abbott Laboratories
Patent: US6277871 B1, 2001 ;
反应条件
1: 49 percent / pyridinium chlorochromate / CH2Cl2 / 2.5 h / Ambient temperature
2: 21 percent / 3-benzyl-5-(2-hydroxyethyl)-4-methylthiazolium chloride, Et3N / 1.5 h / 80 °C
3: TFA / CH2Cl2 / 3 h / Ambient temperature
4: 35 percent / phosphate buffer pH 9.0 / 0.5 h / 100 °C / var. pH
View Scheme
参考文献
Hofmann, Thomas; Schieberle, Peter
Journal of Agricultural and Food Chemistry, 1998 , vol. 46, # 6 p. 2270 - 2277
