4-氨基-N-甲基苯磺酰胺合成路线 （共 15 条）
反应条件
hydrogen; nickel in methanol T=25°C; P=258.6 Torr; 20 h;
参考文献
Khanna, Ish K.; Weier, Richard M.; Yu, Yi; Collins, Paul W.; Miyashiro, Julie M.; Koboldt, Carol M.; Veenhuizen, Amy W.; Currie, Jerry L.; Seibert, Karen; Isakson, Peter C.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 11 p. 1619 - 1633
反应条件
water; potassium hydroxide in methanol T=65°C; 24 h;
参考文献
Barbosa, Maria Leticia De Castro; Lima, Lidia Moreira; Tesch, Roberta; Sant'Anna, Carlos Mauricio R.; Totzke, Frank; Kubbutat, Michael H.G.; Schaechtele, Christoph; Laufer, Stefan A.; Barreiro, Eliezer J.
European Journal of Medicinal Chemistry, 2014 , vol. 71, p. 1 - 14
反应条件
triethylamine in ethanol T=20 - 80°C; 24 h;
参考文献
AstraZeneca AB
Patent: EP1214318 B1, 2003 ;
Location in patent: Page/Page column 37 ;
反应条件
1: 98 percent / diethyl ether; H2O / 16 h / Ambient temperature 2: 100 percent / H2 / Raney-Ni / methanol / 20 h / 25 °C / 258.6 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 11 p. 1619 - 1633
反应条件
1: ethanol; diethyl ether 2: aqueous hydrochloric acid View Scheme
参考文献
Proceedings of the Royal Society of London, Series B: Biological Sciences, , vol. 133, p. 20,30
反应条件
1: acetic acid; sodium acetate / 0.5 h / 20 °C 2: 0.5 h / 60 °C 3: dichloromethane; tetrahydrofuran / 0.5 h / 20 °C 4: potassium hydroxide; water / methanol / 24 h / 65 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 71, p. 1 - 14
反应条件
1: 0.5 h / 60 °C 2: dichloromethane; tetrahydrofuran / 0.5 h / 20 °C 3: potassium hydroxide; water / methanol / 24 h / 65 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 71, p. 1 - 14
参考文献
Journal of the Chemical Society, , p. 751
反应条件
1.1: calcium carbonate / dichloromethane; water / 0 - 20 °C / 760.05 Torr / |Inert atmosphere 2.1: sodium methylate / 0.25 h / 20 °C / 760.05 Torr / |Inert atmosphere 2.2: 1 h / 760.05 Torr / |Inert atmosphere 2.3: 20 °C / 760.05 Torr / |Inert atmosphere 3.1: hydrazine / ethanol / 3 h / 65 °C / 760.05 Torr / |Inert atmosphere View Scheme
