(S)-1-(2-氟苯基)乙醇合成路线 （共 12 条）
反应条件
RuCl2[(R)-binap][(R,R)-dpen]; potassium tert-butylate; hydrogen in isopropyl alcohol T=26 - 30°C; P=3040 Torr; 3 h;
参考文献
Journal of the American Chemical Society, , vol. 120, # 51 p. 13529 - 13530
反应条件
1: With benzo[1,3,2]dioxaborole; rhodium complex 10 in toluene T=20°C; Addition; Hydroboration; 2 h; 2: With sodium hydroxide; water; dihydrogen peroxide in toluene T=20°C; Oxidation; 2 h; Title compound not separated from byproducts;
参考文献
Chemistry - A European Journal, , vol. 5, # 4 p. 1320 - 1330
反应条件
dimethylsulfide borane complex; (S)-B-nBu-CBS catalyst in tetrahydrofuran 0.166667 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Tetrahedron, , vol. 52, # 2 p. 589 - 598
反应条件
sodium hydroxide; water in toluene T=60°C; 1 h;
参考文献
EP1935866 A1, ;
Page/Page column 15 ;
反应条件
1: trimethylaluminum With 1,4-diaza-bicyclo[2.2.2]octane in toluene T=0°C; 2: ortho-fluorobenzaldehyde With [(R)-1,1'-binaphthyl-2,2'-diyldioxy]{bis[(S)-(1-phenylethyl)]amino}phosphine; bis(acetylacetonate)nickel(II) in tetrahydrofuran T=5°C; 1 h; Title compound not separated from byproducts;
参考文献
Angewandte Chemie - International Edition, , vol. 44, # 15 p. 2232 - 2234
反应条件
titanium(IV) isopropylate in hexane T=-35°C; 3 h; Title compound not separated from byproducts.;
参考文献
Organic Letters, , vol. 9, # 10 p. 1927 - 1929
反应条件
1: With (R)-1,1'-bis(diphenylphosphino)-2,2'-binapthyl; [Rh(COD)2](1+)*BF4(1-) in ethylene glycol dimethyl ether T=-78 - 20°C; 2: With sodium hydroxide; dihydrogen peroxide in ethylene glycol dimethyl ether T=0 - 20°C; 2 h; Further stages. Title compound not separated from byproducts.;
参考文献
Journal of Fluorine Chemistry, , vol. 128, # 7 p. 827 - 831
反应条件
titanium(IV) isopropylate; zinc(II) chloride in toluene T=-78 - -30°C;
参考文献
Tetrahedron Letters, , vol. 48, # 17 p. 2989 - 2991
反应条件
Arthrobacter atrocyaneus in N,N-dimethyl-formamide T=32°C; 48 h; Microbiological reaction;
参考文献
Journal of Molecular Catalysis B: Enzymatic, , vol. 83, p. 23 - 28
反应条件
C32H31Cl2N4OPRu; potassium isopropoxide T=30°C; P=750.075 Torr; 0.5 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Chemistry - A European Journal, , vol. 18, # 35 p. 10843 - 10846
