3-氰基-4-氟苯甲酸合成路线

参考文献

Woo, L. W. Lawrence; Bubert, Christian; Sutcliffe, Oliver-B.; Smith, Andrew; Chander, Surinder K.; Mahon, Mary F.; Purohit, Atul; Reed, Michael J.; Potter, Barry V. L.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 15 p. 3540 - 3560

171050-06-93-氰基-4-氟苯甲酸

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SmithKline Beecham Corporation
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179897-89-32-氟-5-溴苯腈

171050-06-93-氰基-4-氟苯甲酸

参考文献

Ku, Thomas W.; Ali, Fadia E.; Bondinell, William E.; Erhard, Karl F.; Huffmann, William F.; et al.
Tetrahedron Letters, 1997 , vol. 38, # 18 p. 3131 - 3134

77771-02-93-溴-4-氟苯甲醛

171050-06-93-氰基-4-氟苯甲酸

参考文献

WO2011/71570 A1, ;

67-56-1甲醇+

171050-06-93-氰基-4-氟苯甲酸

676602-31-6

参考文献

SoftCure Pharmaceuticals AB
Patent: WO2008/152142 A1, 2008 ;
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171050-06-93-氰基-4-氟苯甲酸+

74-88-4甲基碘

676602-31-6

参考文献

VERTEX PHARMACEUTICALS INCORPORATED; HADIDA-RUAH, Sara, Sabina; ARUMUGAM, Vijayalaksmi; DENINNO, Michael, Paul; FRIEMAN, Bryan, A.; KALLEL, Edward, Adam; MILLER, Mark, Thomas; UY, Johnny; ZHOU, Jinglan
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75-36-5乙酰氯+

171050-06-93-氰基-4-氟苯甲酸

676602-31-6

参考文献

Bayer Schering Pharma Aktiengesellschaft
Patent: EP1897885 A1, 2008 ;

171050-06-93-氰基-4-氟苯甲酸+

115-11-7异丁烯

171050-07-0

参考文献

Ku, Thomas W.; Ali, Fadia E.; Bondinell, William E.; Erhard, Karl F.; Huffmann, William F.; et al.
Tetrahedron Letters, 1997 , vol. 38, # 18 p. 3131 - 3134

171050-06-93-氰基-4-氟苯甲酸

258273-31-3

参考文献

GLAXO WELLCOME HOUSE
Patent: US2012/283297 A1, 2012 ;

171050-06-93-氰基-4-氟苯甲酸+

100-51-6苯甲醇

946007-61-0

参考文献

Woo, L. W. Lawrence; Bubert, Christian; Sutcliffe, Oliver-B.; Smith, Andrew; Chander, Surinder K.; Mahon, Mary F.; Purohit, Atul; Reed, Michael J.; Potter, Barry V. L.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 15 p. 3540 - 3560