5-(N-叔丁氧羰基氨基)-2-氯吡啶合成路线 （共 17 条）
反应条件
1: (6-chloro-pyridin-3-yl)-carbamic acid, tert-butyl ester With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in hexanes; diethyl ether T=-75 - -10°C; 2 h; 2: carbon dioxide in hexanes; diethyl ether T=-75 - 20°C; 3: With hydrogenchloride in water pH=5; Product distribution / selectivity;
参考文献
WARNER-LAMBERT COMPANY LLC
Patent: WO2005/16926 A1, 2005 ;
Location in patent: Page/Page column 114-115 ;
WO 2005/016926 A1
反应条件
n-butyllithium; N,N,N',N,-tetramethylethylenediamine in diethyl ether
参考文献
Warner-Lambert Company
Patent: US5654307 A1, 1997 ;
US 5654307 A
反应条件
n-butyllithium in diethyl ether T=-78 - -15°C; 2 h;
参考文献
Wyeth Holdings Corporation
Patent: EP1171440 B1, 2004 ;
Location in patent: Page 59 ;
反应条件
n-butyllithium; N,N,N',N,-tetramethylethylenediamine T=-78 - 0°C; 2 h;
参考文献
Gavai, Ashvinikumar V.; Norris, Derek J.; Han, Wen-Ching; Vite, Gregory D.; Fink, Brian E.; Tokarski, John S.
Patent: US2005/192310 A1, 2005 ;
Location in patent: Page/Page column 28 ;
反应条件
1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / |Inert atmosphere
1.2: 4 h / -78 °C
2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / |Inert atmosphere
2.2: 3 h / 0 °C
3.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C
View Scheme
参考文献
Helsinn Healthcare SA; Fadini, Luca; Manini, Peter; Pietra, Claudio; Giuliano, Claudio; Lovati, Emanuela; Cannella, Roberta; Venturini, Alessio; Stella, Valentino J.
Patent: US8426450 B1, 2013 ;
反应条件
n-butyllithium; N,N,N',N,-tetramethylethylenediamine; iodine in diethyl ether
T=-78 - -10°C; 18 h;
参考文献
Cooper, Laura C.; Chicchi, Gary G.; Dinnell, Kevin; Elliott, Jason M.; Hollingworth, Gregory J.; Kurtz, Marc M.; Locker, Karen L.; Morrison, Denise; Shaw, Duncan E.; Tsao, Kwei-Lan; Watt, Alan P.; Williams, Angela R.; Swain, Christopher J.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 9 p. 1233 - 1236
反应条件
N,N,N',N,-tetramethylethylenediamine; iodine
参考文献
Dinnell, Kevin; Elliott, Jason Matthew; Hollingworth, Gregory John; Shaw, Duncan Edward
Patent: US2002/22624 A1, 2002 ;
