4-甲氧基-3-甲基联苯合成路线 （共 53 条）
反应条件
morpholine; K3PO4*3H2O; NHC-Pd(II)-Im
T=110°C; Suzuki-Miyaura coupling; 24 h; Inert atmosphere;
参考文献
Wang, Zhan-Yong; Chen, Gao-Qi; Shao, Li-Xiong
Journal of Organic Chemistry, 2012 , vol. 77, # 15 p. 6608 - 6614
反应条件
in tetrahydrofuran
T=110°C; Inert atmosphere;
参考文献
Minami, Hiroki; Wang, Xuan; Wang, Chao; Uchiyama, Masanobu
European Journal of Organic Chemistry, 2013 , # 35 p. 7891 - 7894
反应条件
trichlorophosphate
1.) 30 deg C, 30 min; 2.) 6 h;
参考文献
Suresh Chander Rao, M.; Krishna Rao, G. S.
Synthesis, 1987 , # 3 p. 231 - 233
反应条件
1.1: 73 percent / diethyl ether / 0 - 20 °C
2.1: TBAF / tetrahydrofuran
2.2: 85 percent / TBAF; (t-Bu)3P / [(allyl)PdCl]2 / tetrahydrofuran / 1 h / Heating
View Scheme
参考文献
Denmark, Scott E.; Wu, Zhicai
Organic Letters, 1999 , vol. 1, # 9 p. 1495 - 1498
反应条件
morpholine; K3PO4*3H2O; NHC-Pd(II)-Im
T=120°C; Suzuki-Miyaura coupling; 24 h; Inert atmosphere;
参考文献
Wang, Zhan-Yong; Chen, Gao-Qi; Shao, Li-Xiong
Journal of Organic Chemistry, 2012 , vol. 77, # 15 p. 6608 - 6614
反应条件
diethyl ether
Erhitzen des Reaktionsprodukts mit Essigsaeure, Acetanhydrid und Naphthalin-2-sulfonsaeure und anschliessend mit Schwefel;
参考文献
Dauben; Tanabe
Journal of the American Chemical Society, 1953 , vol. 75, p. 4969,4972
反应条件
1: 94 percent / pyridine / 12 h / 20 °C
2: 97 percent / Pd(dba)2; 2-dicyclohexylphosphinobiphenyl; TBAF / tetrahydrofuran / 6 h / Heating
View Scheme
参考文献
Seganish, W. Michael; DeShong, Philip
Journal of Organic Chemistry, 2004 , vol. 69, # 4 p. 1137 - 1143
反应条件
1: zinc / tetrahydrofuran; N,N-dimethyl-formamide / 20 °C
2: sulfuric acid / dichloromethane / 0.2 h / 20 °C
View Scheme
参考文献
He, Yan; Zhang, Xin-Ying; Cui, Liang-Yan; Fan, Xue-Sen
Chemistry - An Asian Journal, 2013 , vol. 8, # 4 p. 717 - 722
反应条件
1.1: tert.-butyl lithium / diethyl ether; pentane / 0.5 h / -78 °C / |Inert atmosphere
1.2: -78 - 0 °C
2.1: tetrahydrofuran / 110 °C / |Inert atmosphere
View Scheme
参考文献
Minami, Hiroki; Wang, Xuan; Wang, Chao; Uchiyama, Masanobu
European Journal of Organic Chemistry, 2013 , # 35 p. 7891 - 7894
反应条件
C34H38Cl2N4Pd; caesium carbonate in 1,4-dioxane
T=100°C; Suzuki coupling; 25 h;
参考文献
Morgan, Brad P.; Galdamez, Gabriela A.; Gilliard Jr., Robert J.; Smith, Rhett C.
Dalton Transactions, 2009 , # 11 p. 2020 - 2028
