(1-氮杂双环[2.2.2]-3-辛基)-(4-甲氧基苄基)-胺合成路线 (共 8 条)
反应条件
trifluoroacetic acid in dichloromethane T=0°C; 2 h;
参考文献
Obrecht; Bohdal; Broger; Bur; Lehmann; Ruffieux; Schonholzer; Spiegler; Muller
Helvetica Chimica Acta, 1995 , vol. 78, # 3 p. 563 - 580
反应条件
1: 1-hydroxybenzotriazole / acetonitrile 2: hydrogen / Pd/C / methanol / 2 h / cooling View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 15 p. 4966 - 4973
反应条件
hydrogen; palladium on activated charcoal in methanol 2 h; cooling;
参考文献
Journal of Organic Chemistry, , vol. 69, # 15 p. 4966 - 4973
反应条件
1: 1-hydroxybenzotriazole / acetonitrile 2: hydrogen / Pd/C / methanol / 2 h / cooling View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 15 p. 4966 - 4973
反应条件
1.1: IBCF; NMM / tetrahydrofuran 1.2: 26.2 percent / dimethylformamide; tetrahydrofuran / 0 - 4 °C 2.1: aq. HCl / dioxane View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 14 p. 3591 - 3599
反应条件
1: ethyl acetate / 3 h / -15 - 20 °C 2: 90.6 percent / TFA / CH2Cl2 / 3 h / 0 - 20 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 9, # 15 p. 2701 - 2713
反应条件
1.1: sodium hydroxide / 1,4-dioxane; water / 6.33 h / 0 - 20 °C 1.2: pH 2 - 3 2.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran / 0 - 20 °C 3.1: methanol; acetyl chloride / 2 h / 0 °C View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 353, # 17 p. 3129 - 3133
参考文献
Journal of the Chemical Society, , p. 371,378