2-氨基-3-溴-5-甲基吡啶合成路线 （共 23 条）
反应条件
acetic anhydride; acetic acid
参考文献
PFIZER INC.
Patent: EP842924 A1, 1998 ;
EP 0842924 A1
反应条件
1: With hydrogenchloride; sodium nitrite in water T=0°C; 2: With ammonia in water
参考文献
ASTRAZENECA AB
Patent: WO2006/25783 A1, 2006 ;
Location in patent: Page/Page column 144 ;
WO 2006/025783 A1
参考文献
Dow AgroSciences LLC
Patent: US5968875 A1, 1999 ;
反应条件
1: With hydrogen bromide in water 2: With bromine in water T=0 - 5°C; 0.166667 h; 3: With sodium hydroxide; sodium nitrite more than 3 stages;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2008/16184 A1, 2008 ;
Location in patent: Page/Page column 187-188 ;
反应条件
sodium hydroxide; palladium diacetate; triphenylphosphine in ethanol 48 h; RefluxInert atmosphere;
参考文献
Bessmertnykh, Alla; Douaihy, Christiane Morkos; Muniappan, Sankar; Guilard, Roger
Synthesis, 2008 , # 10 art. no. P00808SS, p. 1575 - 1579
反应条件
1: dichloromethane / 48 h / 22 °C 2: triethylamine / dichloromethane / 1 h / 22 °C 3: dichloromethane / 24 h / Reflux 4: palladium(II) dichloride bis[bis(diphenylphosphine)ferrocene]; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16.5 h / 22 - 120 °C / Inert atmosphere 5: hydrogenchloride; water / N,N-dimethyl-formamide / 22 °C 6: sodium tetrahydroborate / methanol; dichloromethane / 0 - 22 °C View Scheme
参考文献
Zhao, Yunqi; Duan, Shaofeng; Zeng, Xing; Liu, Chunjing; Davies, Neal M.; Li, Benyi; Forrest, M. Laird
Molecular Pharmaceutics, 2012 , vol. 9, # 6 p. 1705 - 1716
反应条件
toluene-4-sulfonic acid in toluene
96 h; Heating / reflux;
参考文献
KINACIA PTY LTD.
Patent: WO2004/16607 A1, 2004 ;
Location in patent: Page 45-46 ;
WO 2004/016607 A1
反应条件
in ethanol
24 h; Heating;
参考文献
Kazock, Jean-Yves; Enguehard-Gueiffier, Cecile; Thery, Isabelle; Gueiffier, Alain
Bulletin of the Chemical Society of Japan, 2005 , vol. 78, # 1 p. 154 - 159
反应条件
1: in ethylene glycol dimethyl ether
T=20°C;
2: in ethanol
2 h; Heating;
参考文献
Enguehard-Gueiffier, Cecile; Huebner, Harald; El Hakmaoui, Ahmed; Allouchi, Hassan; Gmeiner, Peter; Argiolas, Antonio; Melis, Maria Rosaria; Gueiffier, Alain
Journal of Medicinal Chemistry, 2006 , vol. 49, # 13 p. 3938 - 3947
反应条件
in glycerol
0.25 - 0.333333 h; Microwave irradiation;
参考文献
Kaloyanova, Stefka; Crnolatac, Ivo; Lesev, Nedyalko; Piantanida, Ivo; Deligeorgiev, Todor
Dyes and Pigments, 2012 , vol. 92, # 3 p. 1184 - 1191
