1: (6-chloro-pyridazine-3-yl)-hydrazine; 1-[(benzyloxy)carbonyl]-3-piperidinecarboxylic acid With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane
T=20°C; 16 h;
2: With acetic acid
T=110°C; 48 h;
3: piperidine With hydrogen; palladium 10 on activated carbon
more than 3 stages;
参考文献
Astellas Pharma Inc.
Patent: EP1640010 A1, 2006 ;
Location in patent: Page/Page column 18 ;
1: in acetonitrile
T=20°C; 0.5 h;
2: With 1,2-dibromo-1,1,2,2-tetrachloroethane in acetonitrile
T=20°C; 2 h;
3: With triethylamine; triphenylphosphine in acetonitrile
T=0 - 20°C; 72 h;
参考文献
Astellas Pharma Inc.
Patent: EP1640010 A1, 2006 ;
Location in patent: Page/Page column 16 ;
