1-(((S)-2-(溴甲基)-3-甲基丁氧基)甲基)苯合成路线 （共 9 条）
反应条件
phosphorus oxytribromide in N,N-dimethyl-formamide T=50°C; 3 h; TemperatureTimeSolvent;
参考文献
CHANGZHOU PHARMACEUTICAL FACTORY; Yin, Xuezhi; Wang, Bing; Ji, Ying; Liu, Mingyuan
Patent: US2013/231509 A1, 2013 ;
Location in patent: Paragraph 0024-0025 ;
反应条件
1: 50 percent / TiCl4 / CH2Cl2 2: 82 percent / LiOH; H2O2 3: 86 percent / LAH / tetrahydrofuran 4: 61 percent / PPh3; NBS / CH2Cl2 View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 37 p. 6337 - 6340
反应条件
1: 50 percent / TiCl4 / CH2Cl2 2: 82 percent / LiOH; H2O2 3: 86 percent / LAH / tetrahydrofuran 4: 61 percent / PPh3; NBS / CH2Cl2 View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 37 p. 6337 - 6340
反应条件
1: 82 percent / LiOH; H2O2 2: 86 percent / LAH / tetrahydrofuran 3: 61 percent / PPh3; NBS / CH2Cl2 View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 37 p. 6337 - 6340
反应条件
1: 86 percent / LAH / tetrahydrofuran 2: 61 percent / PPh3; NBS / CH2Cl2 View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 37 p. 6337 - 6340
反应条件
1: 33 percent / HCl 2: 50 percent / TiCl4 / CH2Cl2 3: 82 percent / LiOH; H2O2 4: 86 percent / LAH / tetrahydrofuran 5: 61 percent / PPh3; NBS / CH2Cl2 View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 37 p. 6337 - 6340
反应条件
1: Mg 2: 23 percent / H2 / Pd(OH)2/C 3: 38 percent / TPAP; NMMO 4: 65 percent / 2-hydroxypyridine; Et3N 5: TMSCl; phenol / CH2Cl2 View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 37 p. 6337 - 6340
反应条件
1: Mg
2: 23 percent / H2 / Pd(OH)2/C
3: 38 percent / TPAP; NMMO
4: 65 percent / 2-hydroxypyridine; Et3N
View Scheme
参考文献
Dong, Hua; Zhang, Zhi-Liu; Huang, Jia-Hui; Ma, Rujian; Chen, Shu-Hui; Li, Ge
Tetrahedron Letters, 2005 , vol. 46, # 37 p. 6337 - 6340
反应条件
1: Mg
2: 23 percent / H2 / Pd(OH)2/C
3: 38 percent / TPAP; NMMO
View Scheme
参考文献
Dong, Hua; Zhang, Zhi-Liu; Huang, Jia-Hui; Ma, Rujian; Chen, Shu-Hui; Li, Ge
Tetrahedron Letters, 2005 , vol. 46, # 37 p. 6337 - 6340
