1: in tetrahydrofuran
T=-40°C; 1 h;
2: With hydrogenchloride; ammonium chloride in tetrahydrofuran; water
T=20°C; 0.25 h;
3: With sodium hydroxide in tetrahydrofuran; water
参考文献
Ajinomoto Co., Inc.
Patent: EP1878734 A1, 2008 ;
Location in patent: Page/Page column 14 ;
1: in diethyl ether
T=0°C; Grignard reaction; Inert atmosphereCooling with ice;
2: With water; ammonium chloride in diethyl ether
Grignard reaction; Inert atmosphere;
参考文献
Palmer, Cory; Morra, Nicholas A.; Stevens, Andrew C.; Bajtos, Barbora; Machin, Ben P.; Pagenkopf, Brian L.
Organic Letters, 2009 , vol. 11, # 24 p. 5614 - 5617
