1: With n-butyllithium in tetrahydrofuran; hexane T=-70°C; 2 h; Inert atmosphere; 2: With tri-isopropoxy-borane in tetrahydrofuran; hexane T=-70 - 20°C; 3.5 h; Inert atmosphere; 3: With hydrogenchloride in tetrahydrofuran; hexane; water T=20°C; 2 h;

1: potassium phosphate / tris-(dibenzylideneacetone)dipalladium(0); (Me)CgPPh / water; tetrahydrofuran / 2.5 h / 65 °C / Inert atmosphere 2: potassium carbonate / N,N-dimethyl-formamide / Inert atmosphere 3: potassium phosphate / tris-(dibenzylideneacetone)dipalladium(0); t-Bu Brett Phos / tetrahydrofuran / 20 h / 20 - 90 °C / Inert atmosphere View Scheme