(1S,3S)-1-(1-苯乙基)-5-氧-3-吡咯烷甲酸合成路线 （共 8 条）
反应条件
1: 4.25 h; Heating; 2: in ethanol 0.25 h; Heating; Further stages.;
参考文献
Walker, Daniel P.; Acker, Brad A.; Jacobsen, E. Jon; Wishka, Donn G.
Journal of Heterocyclic Chemistry, 2008 , vol. 45, # 1 p. 247 - 257
参考文献
Walker, Daniel Patrick; Piotrowski, David W.; Jacobsen, Eric Jon; Acker, Brad A.; Myers, Jason K.; Groppi JR., Vincent E.
Patent: US2003/236279 A1, 2003 ;
Location in patent: Page 30 ;
反应条件
T=160°C; 4 h; Neat (no solvent)Heating with oil bath;
参考文献
Yoshitomi Pharmaceutical Industries, Ltd.
Patent: US5864039 A1, 1999 ;
US 5864039 A
参考文献
Arvanitis, Elena; Motevalli, Majid; Wyatt, Peter B.
Tetrahedron Letters, 1996 , vol. 37, # 24 p. 4277 - 4280
反应条件
1: With dimethylsulfide borane complex in tetrahydrofuran T=5 - 25°C; 5 h; 2: With sodium hydrogencarbonate in tetrahydrofuran
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2011/201608 A1, 2011 ;
Location in patent: Page/Page column 17 ;
US 20110201608 A1
反应条件
ammonia; sodium in tert-butyl alcohol T=-33°C; 1 h;
参考文献
Arvanitis, Elena; Motevalli, Majid; Wyatt, Peter B.
Tetrahedron Letters, 1996 , vol. 37, # 24 p. 4277 - 4280
反应条件
lithium aluminum hidride in diethyl ether 3 h; Heating;
参考文献
Walker, Daniel P.; Acker, Brad A.; Jacobsen, E. Jon; Wishka, Donn G.
Journal of Heterocyclic Chemistry, 2008 , vol. 45, # 1 p. 247 - 257
反应条件
1: lithium aluminium tetrahydride / diethyl ether / 2 h / 50 °C / Heating / reflux
2: thionyl chloride; nitrogen / chloroform / 1.25 h / Heating / reflux
3: nitrogen / dimethyl sulfoxide / 100 °C
4: methanol / 100 h / 0 - 20 °C
View Scheme
参考文献
Walker, Daniel Patrick; Piotrowski, David W.; Jacobsen, Eric Jon; Acker, Brad A.; Myers, Jason K.; Groppi JR., Vincent E.
Patent: US2003/236279 A1, 2003 ;
