4-苯甲酰基-5-甲基-3-异恶唑羧酸乙酯合成路线 （共 6 条）
反应条件
sodium methylate in methanol T=0 - 25°C; 3 h; Product distribution / selectivity;
参考文献
LABORATORIOS ALMIRALL, S.A.
Patent: WO2008/107064 A1, 2008 ;
Location in patent: Page/Page column 6;7 ;
反应条件
1-methyl-piperidine; copper diacetate in chloroform T=60°C; 72 h; regioselective reaction;
参考文献
Trogu, Elena; Cecchi, Luca; De Sarlo, Francesco; Guideri, Luca; Ponticelli, Fabio; Machetti, Fabrizio
European Journal of Organic Chemistry, 2009 , # 34 p. 5971 - 5978
反应条件
sodium ethanolate in ethanol
参考文献
Giovannoni, Maria Paola; Vergelli, Claudia; Ghelardini, Carla; Galeotti, Nicoletta; Bartolini, Alessandro; Dal Piaz, Vittorio
Journal of Medicinal Chemistry, 2003 , vol. 46, # 6 p. 1055 - 1059
反应条件
triethylamine in diethyl ether
参考文献
Renzi,G. et al.
Gazzetta Chimica Italiana, 1968 , vol. 98, p. 656 - 666
参考文献
Renzi,G. et al.
Gazzetta Chimica Italiana, 1968 , vol. 98, p. 656 - 666
反应条件
1: ethanol / Heating 2: aq. HCl / ethanol / 5 h / Heating View Scheme
参考文献
Renzi,G.; Pinzanti,S.
Farmaco, Edizione Scientifica, 1969 , vol. 24, p. 885 - 892
