1: meta-carboxy iodo-benzene With 1,1'-carbonyldiimidazole in N,N-dimethyl-formamide T=40°C; 1 h; 2: tert-butyl alcohol With 1,8-diazabicyclo[5.4.0]undec-7-ene in N,N-dimethyl-formamide T=40°C;

4-(N,N-dimethlyamino)pyridine in dichloromethane 18 h;

sulfuric acid in dichloromethane T=20°C; 48 h;

1: With phenyllithium in tetrahydrofuran; diethyl ether; cyclohexane T=-28°C; Flow reactor; 2: With N-fluoro-N-(phenylsulfonyl)benzene-sulfonamide in tetrahydrofuran; diethyl ether; cyclohexane T=-28°C; Flow reactor; Reagent/catalyst;

1: With phenyllithium in tetrahydrofuran; diethyl ether; cyclohexane T=-48°C; 0.000105556 h; 2: With tert-butyl alcohol in tetrahydrofuran; diethyl ether; cyclohexane T=-48°C; 0.000638889 h;

1.1: triethylamine / tetrakis(triphenylphosphine) palladium(0); copper(l) iodide / tetrahydrofuran / 0.17 h / Inert atmosphere 1.2: 18 h 2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 17 h / 0 - 20 °C / Inert atmosphere 3.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C 3.2: 20 h / 65 °C View Scheme

1: 3-iodobenzoic acid tert-butyl ester With phenyllithium in tetrahydrofuran; diethyl ether; cyclohexane T=0°C; 2.77778E-06 h; 2: methyl iodide in tetrahydrofuran; diethyl ether; cyclohexane T=0°C; 0.000638889 h;