17356-08-0合成路线 （共 1741 条）
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride
1.) aq. EtOH, reflux, 3 h, 2.) aq. EtOH, 60 deg C; Yield given. Multistep reaction;
参考文献
Jian-Hua, Wang; Zhen, Zhang; Yong-Lai, Feng
Synthetic Communications, 1993 , vol. 23, # 3 p. 373 - 377
参考文献
Bastien,G. et al.
Bulletin de la Societe Chimique de France, 1979 , vol. <II>, p. 606 - 613
反应条件
in ethanol
T=100°C; 0.25 h; microwave irradiation;
参考文献
UNIVERSITY OF SOUTH FLORIDA
Patent: WO2007/62222 A2, 2007 ;
Location in patent: Page/Page column 47; 49; 70 ;
参考文献
Podesva,C. et al.
Canadian Journal of Chemistry, 1962 , vol. 40, p. 1403 - 1407
反应条件
in methanol
T=20 - 80°C; 102 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/58752 A1, 2004 ;
Location in patent: Page 66 ;
WO 2004/058752 A1
反应条件
ammonium sulfate
T=70 - 180°C; Dimerization; 4 h;
参考文献
Voronkov, M. G.; Vlasova, N. N.; Pestunovich, A. E.
Russian Journal of General Chemistry, 1998 , vol. 68, # 5 p. 770 - 774
Zhurnal Obshchei Khimii, 1998 , vol. 68, # 5 p. 817 - 821
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride
1.) aq. EtOH, reflux, 3 h, 2.) aq. EtOH, 60 deg C; Yield given. Multistep reaction;
参考文献
Jian-Hua, Wang; Zhen, Zhang; Yong-Lai, Feng
Synthetic Communications, 1993 , vol. 23, # 3 p. 373 - 377
反应条件
iodine; potassium iodide in methanol; water
0.5 h; Ambient temperature;
参考文献
Park, Kyong-Hwi; Daves, G. Doyle
Journal of Organic Chemistry, 1980 , vol. 45, # 5 p. 780 - 785
反应条件
1: 4-methyl-3-oxo-pentanoic acid ethyl ester With thionyl chloride in dichloromethane
T=0 - 20°C; 1 h;
2: thiourea in 1,4-dioxane; water
T=80°C;
参考文献
ELI LILLY AND COMPANY
Patent: WO2007/92751 A2, 2007 ;
Location in patent: Page/Page column 18 ;
反应条件
in ethanol
T=23 - 100°C; 1 h;
参考文献
GRÜNENTHAL GMBH; LUCAS, Simon; Kühnert, Sven; Bahrenberg, Gregor; Schröder, Wolfgang
Patent: US2014/148454 A1, 2014 ;
Location in patent: Paragraph 0716 ;
