2-甲基-3-氧代戊酸甲酯合成路线 （共 21 条）
反应条件
boron trifluoride diethyl etherate
2 h; Heating;
参考文献
Kashima, Choji; Takahashi, Katsumi; Fukusaka, Kiyoshi
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 6 p. 1775 - 1778
反应条件
potassium carbonate in tetrahydrofuran
Heating;
参考文献
Jones, Simon M.; Urch, Jonathan E.; Brun, Reto; Harwood, John L.; Berry, Colin; Gilbert, Ian H.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 4 p. 683 - 692
反应条件
hydrogenchloride; tetra-n-butylammonium tetrafluoroborate; zinc dibromide; zinc
1.) CH2Cl2, RT, 2.) CH2Cl2; Yield given. Multistep reaction;
参考文献
Zylber, N.; Zylber, J.; Rollin, Y.; Dunach, E.; Perichon, J.
Journal of Organometallic Chemistry, 1993 , vol. 444, # 1.2. p. 1 - 4
反应条件
(i) CrO3, H2SO4, (ii) /BRN= 102415/, Et2O; Multistep reaction;
参考文献
Chatterjee,S.
Tetrahedron Letters, 1979 , p. 3249 - 3252
参考文献
Newman; Evans
Journal of the American Chemical Society, 1955 , vol. 77, p. 946
反应条件
1.1: sodium hydride / tetrahydrofuran / 0.17 h / Inert atmosphere; Cooling with ice
1.2: 15 h / 20 °C / Inert atmosphere; Cooling with ice
2.1: lithium hydroxide hydrate / tetrahydrofuran; water / 12 h / Inert atmosphere; Reflux
2.2: pH 1 - 2 / Inert atmosphere
View Scheme
参考文献
Krenske, Elizabeth H.; Houk; Lim, Daniel; Wengryniuk, Sarah E.; Coltart, Don M.
Journal of Organic Chemistry, 2010 , vol. 75, # 24 p. 8578 - 8584
反应条件
1: 61.7 percent / bromine / CHCl3 / 10 h / 20 °C
2: 91 percent / triethylamine / CH2Cl2 / 6 h / 20 °C
3: 89 percent / potassium hydroxide / H2O; ethanol / 3 h / 20 °C
4: 83 percent / ethyldiisopropylamine / CH2Cl2 / 0 °C
View Scheme
参考文献
Kamal, Ahmed; Shaik, Ahmad Ali; Azeeza, Shaik; Malik, M. Shaheer; Sandbhor, Mahendra
Tetrahedron Asymmetry, 2006 , vol. 17, # 20 p. 2890 - 2895
反应条件
pyridinium hydrobromide perbromide in acetic acid
Ambient temperature;
参考文献
Wang, Chia-Lin J.; Salvino, J. M.
Tetrahedron Letters, 1984 , vol. 25, # 46 p. 5243 - 5246
反应条件
1: 61.7 percent / bromine / CHCl3 / 10 h / 20 °C
2: 91 percent / triethylamine / CH2Cl2 / 6 h / 20 °C
View Scheme
参考文献
Jones, Simon M.; Urch, Jonathan E.; Brun, Reto; Harwood, John L.; Berry, Colin; Gilbert, Ian H.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 4 p. 683 - 692
反应条件
1.1: sodium methylate / methanol / 12 h / 0 - 20 °C
1.2: 20 °C / Cooling with ice
2.1: pig liver esterase / 20 °C / pH 7 / aq. phosphate buffer; Resolution of racemate
View Scheme
参考文献
Dubberke, Silke; Abbas, Muhammad; Westermann, Bernhard
Beilstein Journal of Organic Chemistry, 2011 , vol. 7, p. 421 - 425
