4-(1-环己烯基)苯胺合成路线 （共 19 条）
反应条件
sodium hydroxide; stannous chloride; sodium chloride in ethanol; n-heptane; water; ethyl acetate
参考文献
NOVO NORDISK A/S; AGOURON PHARMACEUTICALS, INC.
Patent: EP1183229 B1, 2005 ;
Location in patent: Page/Page column 162 ;
反应条件
potassium hydroxide in methanol T=60°C; 6 h;
参考文献
Johnson, Peter Y.; Pan, Robert; Wen, Jing Quan; Halfman, Clarke J.
Journal of Organic Chemistry, 1981 , vol. 46, # 10 p. 2049 - 2054
反应条件
hydrogenchloride T=200°C; P=14 Torr;
参考文献
v.Braun
Justus Liebigs Annalen der Chemie, 1929 , vol. 472, p. 34
反应条件
P=12 Torr; beim Erhitzen;
参考文献
v.Braun
Justus Liebigs Annalen der Chemie, 1929 , vol. 472, p. 34
反应条件
1: 1.) Mg / 1.) benzene, ether, 2.) reflux, 4 h 2: 71 percent / dimethylformamide / 72 h / 120 °C 3: 76 percent / 30percent H2O2, K2CO3 / acetone; H2O / 3 h / 40 °C 4: 66 percent / CH3ONa, bromine / methanol; dioxane / 0.5 h / 40 °C 5: aq. KOH / methanol / 6 h / 60 °C View Scheme
参考文献
Johnson, Peter Y.; Pan, Robert; Wen, Jing Quan; Halfman, Clarke J.
Journal of Organic Chemistry, 1981 , vol. 46, # 10 p. 2049 - 2054
反应条件
1: 71 percent / dimethylformamide / 72 h / 120 °C 2: 76 percent / 30percent H2O2, K2CO3 / acetone; H2O / 3 h / 40 °C 3: 66 percent / CH3ONa, bromine / methanol; dioxane / 0.5 h / 40 °C 4: aq. KOH / methanol / 6 h / 60 °C View Scheme
参考文献
Johnson, Peter Y.; Pan, Robert; Wen, Jing Quan; Halfman, Clarke J.
Journal of Organic Chemistry, 1981 , vol. 46, # 10 p. 2049 - 2054
反应条件
1: 1.) Mg / 1.) benzene, ether, 2.) reflux, 4 h 2: 71 percent / dimethylformamide / 72 h / 120 °C 3: 76 percent / 30percent H2O2, K2CO3 / acetone; H2O / 3 h / 40 °C 4: 66 percent / CH3ONa, bromine / methanol; dioxane / 0.5 h / 40 °C 5: aq. KOH / methanol / 6 h / 60 °C View Scheme
参考文献
Johnson, Peter Y.; Pan, Robert; Wen, Jing Quan; Halfman, Clarke J.
Journal of Organic Chemistry, 1981 , vol. 46, # 10 p. 2049 - 2054
反应条件
1: 76 percent / 30percent H2O2, K2CO3 / acetone; H2O / 3 h / 40 °C 2: 66 percent / CH3ONa, bromine / methanol; dioxane / 0.5 h / 40 °C 3: aq. KOH / methanol / 6 h / 60 °C View Scheme
参考文献
Johnson, Peter Y.; Pan, Robert; Wen, Jing Quan; Halfman, Clarke J.
Journal of Organic Chemistry, 1981 , vol. 46, # 10 p. 2049 - 2054
反应条件
1: 66 percent / CH3ONa, bromine / methanol; dioxane / 0.5 h / 40 °C 2: aq. KOH / methanol / 6 h / 60 °C View Scheme
参考文献
Johnson, Peter Y.; Pan, Robert; Wen, Jing Quan; Halfman, Clarke J.
Journal of Organic Chemistry, 1981 , vol. 46, # 10 p. 2049 - 2054
反应条件
hydrogenchloride T=200°C;
参考文献
v.Braun
Justus Liebigs Annalen der Chemie, 1929 , vol. 472, p. 34
