in dichloromethane Ambient temperatureDeprotection of various Boc-amino acids was investigated. Effect of concentration of the deprotection reagent on the deprotection rates (t1/2) is determined.; Kinetics;
1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 20 °C 2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 20 °C 3: tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Siciliano, Carlo; De Marco, Rosaria; Guidi, Ludovica Evelin; Spinella, Mariagiovanna; Liguori, Angelo
Journal of Organic Chemistry, 2012 , vol. 77, # 23 p. 10575 - 10582
1: L-Val hydrochloride With sodium carbonate; sodium hydroxide in 2-methyl tetrahydrofuran; water 2: methyl chloroformate in 2-methyl tetrahydrofuran; water T=0 - 5°C; 6 h;
