N,N-二甲基环己烷羧酰胺合成路线 （共 20 条）
反应条件
Pd/C; hydrogen
T=160°C; 16 h;
参考文献
Beamson, Graham; Papworth, Adam J.; Philipps, Charles; Smith, Andrew M.; Whyman, Robin
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 5 p. 869 - 883
反应条件
tri-ruthenium(0)dodecacarbonyl; hydrogen; molybdenum hexacarbonate in ethylene glycol dimethyl ether
T=160°C; P=75007.5 Torr; 16 h; Inert atmosphere;
参考文献
Beamson, Graham; Papworth, Adam J.; Philipps, Charles; Smith, Andrew M.; Whyman, Robin
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 5 p. 869 - 883
反应条件
in benzene
12 h; Heating;
参考文献
Levin, Jeremy I.; Turos, Edward; Weinreb, Steven M.
Synthetic Communications, 1982 , vol. 12, # 13 p. 989 - 994
反应条件
Novozym 435 in tert-butyl methyl ether
T=50°C; Molecular sieveEnzymatic reaction;
参考文献
Van Pelt; Teeuwen; Janssen; Sheldon; Dunn; Howard; Kumar; Martinez; Wong
Green Chemistry, 2011 , vol. 13, # 7 p. 1791 - 1798
反应条件
(i) MeCN, (ii) aq. NaOH; Multistep reaction;
参考文献
Hobbs,C.F.; Weingarten,H.
Journal of Organic Chemistry, 1974 , vol. 39, p. 918 - 921
反应条件
HPtCl6·6H2O; 1,1,3,3-tetramethyldisiloxane in tetrahydrofuran; toluene
T=50°C; 5 h; Inert atmosphere;
参考文献
Hanada, Shiori; Tsutsumi, Emi; Motoyama, Yukihiro; Nagashima, Hideo
Journal of the American Chemical Society, 2009 , vol. 131, # 41 p. 15032 - 15040
反应条件
sodium (tert-butylamino)trihydroborate in tetrahydrofuran
T=66°C; 65 h; further reducing agent: sodium (dimethylamino)trihydroborat (NaDMAB); Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Beamson, Graham; Papworth, Adam J.; Philipps, Charles; Smith, Andrew M.; Whyman, Robin
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 5 p. 869 - 883
反应条件
(i) COCl2, CH2Cl2, (ii) Py-N-oxide, Et3N; Multistep reaction;
参考文献
Da Costa,R. et al.
Journal of the American Chemical Society, 1979 , vol. 101, p. 4381 - 4383
反应条件
1: 83 percent / PhMe2SiLi / tetrahydrofuran / 2 h / -78 - -20 °C
2: 83 percent / Pd/C / methanol / 4 h / 20 °C
3: 93 percent / aq. HCl / 18 h / 75 °C
View Scheme
参考文献
Fleming, Ian; Ghosh, Usha; Mack, Stephen R.; Clark, Barry P.
Chemical Communications, 1998 , # 6 p. 711 - 712
反应条件
1: 3-bromo-pyridine With n-butyllithium in diethyl ether
T=-70°C; 0.166667 h;
2: cyclohexanecarboxylic acid dimethylamide in tetrahydrofuran; diethyl ether
参考文献
Kuzenkov
Chemistry of Heterocyclic Compounds, 2003 , vol. 39, # 11 p. 1492 - 1495
