1'-(苯基甲基)-[1,4'-联哌啶]-4'-甲酰胺合成路线 (共 2 条)
反应条件
1: With sulfuric acid in water T=100°C; 0.166667 h; Heating / reflux; 2: With sodium hydroxide in water T=0°C; pH=9;
参考文献
Solvay pharmaceuticals GmbH
Patent: US2007/219214 A1, 2007 ;
Location in patent: Page/Page column 27 ;
US 20070219214 A1
反应条件
1: With magnesium sulfate in N,N-dimethyl acetamide T=55°C; 48 h; 2: With sulfuric acid; water T=100°C; 0.166667 h; 3: With sodium hydroxide in water T=0°C; pH=9;
参考文献
SOLVAY PHARMACEUTICALS GMBH
Patent: WO2007/88181 A1, 2007 ;
Location in patent: Page/Page column 67 ;
WO 2007/088181 A1