1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / ethanol; benzene / 16 h / Inert atmosphere; Reflux 2: methanol; ammonium chloride; magnesium / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Mesangeau, Christophe; Amata, Emanuele; Alsharif, Walid; Seminerio, Michael J.; Robson, Matthew J.; Matsumoto, Rae R.; Poupaert, Jacques H.; McCurdy, Christopher R.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 10 p. 5154 - 5161
1: With molecular sieve; copper diacetate; triethylamine in dichloromethane T=20°C; 16 h; 2: With hydrogenchloride; lithium hydroxide in 1,4-dioxane; water T=20°C; 18 h;
参考文献
Walker, Daniel Patrick; Piotrowski, David W.; Jacobsen, Eric Jon; Acker, Brad A.; Myers, Jason K.; Groppi JR., Vincent E.
Patent: US2003/236279 A1, 2003 ;
Location in patent: Page 34 ;