hydrogen; triethylamine; palladium on activated charcoal in methanol 3 h;

1: 60 percent / β-methyl aspartase; KCl; NH4Cl / MgCl2*6H2O / H2O / 32 °C / pH 9 2: tetrahydrofuran / 0 - 20 °C 3: 2 h / 20 °C 4: 65 percent / N-methylmorpholine; isobutyl chloroformate; sodium borohydride / tetrahydrofuran / 3 h / -20 °C 5: 95 percent / iodine; triphenylphosphane; imidazole / CH2Cl2 / 2 h 6: 73 percent / triethylamine; hydrogen / Pd/C / methanol / 3 h View Scheme

1: tetrahydrofuran / 0 - 20 °C 2: 2 h / 20 °C 3: 65 percent / N-methylmorpholine; isobutyl chloroformate; sodium borohydride / tetrahydrofuran / 3 h / -20 °C 4: 95 percent / iodine; triphenylphosphane; imidazole / CH2Cl2 / 2 h 5: 73 percent / triethylamine; hydrogen / Pd/C / methanol / 3 h View Scheme

1.1: DBU / toluene / Heating 1.2: 81 percent / aq. HCl / 3 h / Heating 2.1: 60 percent / β-methyl aspartase; KCl; NH4Cl / MgCl2*6H2O / H2O / 32 °C / pH 9 3.1: tetrahydrofuran / 0 - 20 °C 4.1: 2 h / 20 °C 5.1: 65 percent / N-methylmorpholine; isobutyl chloroformate; sodium borohydride / tetrahydrofuran / 3 h / -20 °C 6.1: 95 percent / iodine; triphenylphosphane; imidazole / CH2Cl2 / 2 h 7.1: 73 percent / triethylamine; hydrogen / Pd/C / methanol / 3 h View Scheme

1: 2 h / 20 °C 2: 65 percent / N-methylmorpholine; isobutyl chloroformate; sodium borohydride / tetrahydrofuran / 3 h / -20 °C 3: 95 percent / iodine; triphenylphosphane; imidazole / CH2Cl2 / 2 h 4: 73 percent / triethylamine; hydrogen / Pd/C / methanol / 3 h View Scheme

1: 95 percent / iodine; triphenylphosphane; imidazole / CH2Cl2 / 2 h 2: 73 percent / triethylamine; hydrogen / Pd/C / methanol / 3 h View Scheme

1: 65 percent / N-methylmorpholine; isobutyl chloroformate; sodium borohydride / tetrahydrofuran / 3 h / -20 °C 2: 95 percent / iodine; triphenylphosphane; imidazole / CH2Cl2 / 2 h 3: 73 percent / triethylamine; hydrogen / Pd/C / methanol / 3 h View Scheme

hydrogenchloride in water T=110°C; 24 h;

hydrogenchloride in water

1: With Jone's reagent in acetone T=0°C; 0.166667 h; 2: With hydrogenchloride; water T=110°C; 16 h; Sealed glass bomb;