1,4-二氧螺环[4,5]癸烷合成路线 （共 57 条）
反应条件
1: 30 percent / bis<benzyltriethylammonium> dichromate / hexamethylphosphoric acid triamide / 60 - 80 °C
2: 70 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C
3: conc. aq. HCl / tetrahydrofuran / 0.5 h / Ambient temperature
View Scheme
参考文献
Kita, Yasuyuki; Yasuda, Hitoshi; Haruta, Jun-ichi; Segawa, Jun; Tamura, Yasumitsu
Synthesis, 1982 , # 12 p. 1089 - 1091
反应条件
triethylsilane; palladium dichloride; tri-cyclo-hexyl-phosphine in tetrahydrofuran
T=20°C; 0.5 h;
参考文献
Benohoud, Meryem; Tuokko, Sakari; Pihko, Petri M.
Chemistry - A European Journal, 2011 , vol. 17, # 30 p. 8404 - 8413
反应条件
hydrogenchloride in tetrahydrofuran
0.5 h; Ambient temperature; Yield given;
参考文献
Kita, Yasuyuki; Yasuda, Hitoshi; Haruta, Jun-ichi; Segawa, Jun; Tamura, Yasumitsu
Synthesis, 1982 , # 12 p. 1089 - 1091
反应条件
acetic acid in acetonitrile-D3; water
参考文献
Deslongchamps, Pierre; Dory, Yves L.; Li, Shigui
Helvetica Chimica Acta, 1996 , vol. 79, # 1 p. 41 - 50
反应条件
lithium aluminium tetrahydride
Ambient temperature;
参考文献
Leone, Christina L.; Chamberlin, A. Richard
Tetrahedron Letters, 1991 , vol. 32, # 14 p. 1691 - 1694
反应条件
toluene-4-sulfonic acid
参考文献
Grindley, T. Bruce; Cote, Christian J. P.; Wickramage, Chandra
Carbohydrate Research, 1985 , vol. 140, p. 215 - 238
反应条件
1: 1.) AcOH; 2.) triethylamine / 1.) benzene, 34 h, room temp.;
2: 1.) NBS; 2.) triethylamine / 1.) CD3CN, MeOH, 10 min, NMR tube; 2.) CD3CN, MeOH, NMR tube
View Scheme
参考文献
Deslongchamps, Pierre; Dory, Yves L.; Li, Shigui
Helvetica Chimica Acta, 1996 , vol. 79, # 1 p. 41 - 50
参考文献
Kropp, Paul J.; McNeely, Steven A.; Davis, Robert Drummond
Journal of the American Chemical Society, 1983 , vol. 105, # 23 p. 6907 - 6915
反应条件
N-bromosuccinmide; triethylamine
1.) CD3CN, MeOH, 10 min, NMR tube; 2.) CD3CN, MeOH, NMR tube; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Deslongchamps, Pierre; Dory, Yves L.; Li, Shigui
Helvetica Chimica Acta, 1996 , vol. 79, # 1 p. 41 - 50
反应条件
unter Entfernen des entstehenden Wassers;
参考文献
Salmi
Chemische Berichte, 1938 , vol. 71, p. 1803,1807
Full Text Show Details
Sulzbacher; Bergmann; Pariser
Journal of the American Chemical Society, 1948 , vol. 70, p. 2877
