2,4,4-三甲基-2-恶唑合成路线 （共 40 条）
反应条件
(i) nBuLi, (ii) /BRN= 1815228/, (iii) /BRN= 1718733/, H2SO4; Multistep reaction;
参考文献
Meyers,A.I. et al.
Journal of Organic Chemistry, 1974 , vol. 39, p. 2778 - 2783
反应条件
(i) nBuLi, THF, pentane, hexane, (ii) /BRN= 471308/; Multistep reaction;
参考文献
Meyers,A.I. et al.
Journal of Organic Chemistry, 1974 , vol. 39, p. 2778 - 2783
反应条件
1: 4,5-dihydro-2,4,4-trimethyloxazole With lithium diisopropyl amide in tetrahydrofuran T=-98°C; 0.333333 h; 2: N-lt;(4-Chlorophenyl)methylenegt;-2-methyl-2-propanamine N-oxide in tetrahydrofuran T=-98 - 20°C;
参考文献
Tetrahedron Letters, , vol. 42, # 52 p. 9183 - 9186
反应条件
1: LDA / tetrahydrofuran / 0.5 h / -98 °C 2: 70 percent / tetrahydrofuran / 18 h / -98 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 17 p. 2961 - 2969
反应条件
1: 4,5-dihydro-2,4,4-trimethyloxazole With n-butyllithium in tetrahydrofuran T=-78°C; 0.75 h; 2: 4-bromo-benzyl bromide in tetrahydrofuran T=20°C; 3: With hydrogenchloride 1 h; Heating; Further stages.;
参考文献
Stambuli; Stauffer; Shaughnessy; Hartwig
Journal of the American Chemical Society, 2001 , vol. 123, # 11 p. 2677 - 2678
反应条件
hydrogenchloride; n-butyllithium in tetrahydrofuran; ethylene glycol dimethyl ether
参考文献
Neorx Corporation
Patent: US4885153 A1, 1989 ;
参考文献
Beak, Peter; Selling, Gordon W.
Journal of Organic Chemistry, 1989 , vol. 54, # 23 p. 5574 - 5580
反应条件
N,N-di-tert-butylnitroxide; KNH2 1) liq. NH3, -33 deg C, 15 min; 2) irradiation, 5 min, liq. NH3, -33 deg C; Yield given. Multistep reaction;
参考文献
Wong, Jim-Wah; Natalie Jr., Kenneth J.; Nwokogu, Godson C.; Pisipati, Jyothi S.; Flaherty, Patrick T.; Greenwood, Thomas D.; Wolfe, James F.
Journal of Organic Chemistry, 1997 , vol. 62, # 18 p. 6152 - 6159
反应条件
KNH2 1) liq. NH3, -33 deg C, 15 min; 2) irradiation, 120 min, liq. NH3, -33 deg C; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Wong, Jim-Wah; Natalie Jr., Kenneth J.; Nwokogu, Godson C.; Pisipati, Jyothi S.; Flaherty, Patrick T.; Greenwood, Thomas D.; Wolfe, James F.
Journal of Organic Chemistry, 1997 , vol. 62, # 18 p. 6152 - 6159
反应条件
KNH2 1) liq. NH3, -33 deg C, 15 min; 2) irradiation, 5 min, liq. NH3, -33 deg C; further conditions; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Wong, Jim-Wah; Natalie Jr., Kenneth J.; Nwokogu, Godson C.; Pisipati, Jyothi S.; Flaherty, Patrick T.; Greenwood, Thomas D.; Wolfe, James F.
Journal of Organic Chemistry, 1997 , vol. 62, # 18 p. 6152 - 6159
