2,4,4-三甲基-2-恶唑合成路线 （共 40 条）
反应条件
1: 4,5-dihydro-2,4,4-trimethyloxazole With n-butyllithium in tetrahydrofuran T=-78°C; 0.75 h; 2: 4-chloro-benzyl chloride in tetrahydrofuran T=-78 - 20°C; 3: With hydrogenchloride 1 h; Heating;
参考文献
Stauffer, Shaun R.; Hartwig, John F.
Journal of the American Chemical Society, 2003 , vol. 125, # 23 p. 6977 - 6985
反应条件
(i) nBuLi, (ii) /BRN= 635680/, (iii) /BRN= 1718733/, H2SO4; Multistep reaction;
参考文献
Meyers,A.I. et al.
Journal of Organic Chemistry, 1974 , vol. 39, p. 2778 - 2783
反应条件
(i) nBuLi, (ii) /BRN= 385735/, (iii) aq. HCl; Multistep reaction;
参考文献
Meyers,A.I. et al.
Journal of Organic Chemistry, 1974 , vol. 39, p. 2778 - 2783
反应条件
tert-butylhypochlorite
参考文献
Florio, Saverio; Lorusso, Patrizia; Granito, Catia; Luisi, Renzo; Troisi, Luigino
Journal of Organic Chemistry, 2004 , vol. 69, # 15 p. 4961 - 4965
反应条件
tert-butylhypochlorite
T=0 - 20°C;
参考文献
Abbotto, Alessandro; Bradamante, Silvia; Florio, Saverio; Capriati, Vito
Journal of Organic Chemistry, 1997 , vol. 62, # 25 p. 8937 - 8940
反应条件
lithium aluminium tetrahydride in diethyl ether
参考文献
Beger,J.; Hoebold,W.
Journal fuer Praktische Chemie (Leipzig), 1969 , vol. 311, p. 760 - 768
反应条件
n-butyllithium; bromine
Yield given. Multistep reaction;
参考文献
Breton; Andre-Barres; Langlois
Synthetic Communications, 1992 , vol. 22, # 17 p. 2543 - 2554
反应条件
(i) nBuLi, (ii) /BRN= 635704/, (iii) /BRN= 635639/, H2SO4; Multistep reaction;
参考文献
Meyers,A.I. et al.
Journal of Organic Chemistry, 1974 , vol. 39, p. 2778 - 2783
反应条件
diphosphorus pentasulfide; sodium hydroxide in toluene
参考文献
Merck and Co., Inc.
Patent: US6387911 B1, 2002 ;
US 6387911 B1
反应条件
(i) nBuLi, THF, (ii) /BRN= 1699049/; Multistep reaction;
参考文献
Meyers,A.I. et al.
Journal of Organic Chemistry, 1974 , vol. 39, p. 2778 - 2783
