(9ci)-4-甲氧基-1,2-二甲基-1H-苯并咪唑合成路线 （共 4 条）
反应条件
acetic acid in hydrogenchloride
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US6083961 A1, 2000 ;
反应条件
1: 1.) Et3N, diphenyl phosphorazidate / 1.) benzene, reflux, 40 min, 2.) benzene, 40 min
2: 29.9 percent / LiAlH4 / tetrahydrofuran / 1.5 h / 0 - 20 °C
3: 1.) 4 N HCl, 2.) 28percent aq. NH3 / 1.) reflux, 4 h
View Scheme
参考文献
Abe, Yoshito; Kayakiri, Hiroshi; Satoh, Shigeki; Inoue, Takayuki; Sawada, Yuki; Inamura, Noriaki; Asano, Masayuki; Aramori, Ichiro; Hatori, Chie; Sawai, Hiroe; Oku, Teruo; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 1998 , vol. 41, # 21 p. 4062 - 4079
反应条件
1: 29.9 percent / LiAlH4 / tetrahydrofuran / 1.5 h / 0 - 20 °C
2: 1.) 4 N HCl, 2.) 28percent aq. NH3 / 1.) reflux, 4 h
View Scheme
参考文献
Abe, Yoshito; Kayakiri, Hiroshi; Satoh, Shigeki; Inoue, Takayuki; Sawada, Yuki; Inamura, Noriaki; Asano, Masayuki; Aramori, Ichiro; Hatori, Chie; Sawai, Hiroe; Oku, Teruo; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 1998 , vol. 41, # 21 p. 4062 - 4079
反应条件
hydrogenchloride; ammonium hydroxide
1.) reflux, 4 h; Yield given. Multistep reaction;
参考文献
Abe, Yoshito; Kayakiri, Hiroshi; Satoh, Shigeki; Inoue, Takayuki; Sawada, Yuki; Inamura, Noriaki; Asano, Masayuki; Aramori, Ichiro; Hatori, Chie; Sawai, Hiroe; Oku, Teruo; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 1998 , vol. 41, # 21 p. 4062 - 4079
