4-硝基苯酚三氟甲基磺酸酯合成路线 （共 131 条）
反应条件
7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene on polystyrene.HL in acetonitrile T=80°C; Esterification;
参考文献
Boisnard, Sabine; Chastanet, Jaqueline; Zhu, Jieping
Tetrahedron Letters, 1999 , vol. 40, # 42 p. 7469 - 7472
反应条件
caesium carbonate in N,N-dimethyl-formamide T=100°C;
参考文献
Cui, Sun-Liang; Jiang, Zhi-Yong; Wang, Yan-Guang
Synlett, 2004 , # 10 p. 1829 - 1831
反应条件
1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; tripotassium phosphate monohydrate; palladium diacetate / toluene 2: 10 palladium on activated charcoal; hydrogen / ethanol 3: hydrogenchloride; sodium nitrite / water / Cooling with ice View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 3 p. 1397 - 1401
反应条件
1: DIPEA / Pd(PPh3)2Cl2; CuI / dimethylformamide / 48 h / 45 °C 2: aq. NaOH / diethyl ether; methanol / 18 h 3: CuSO4; sodium ascorbate; KHCO3 / 2-methyl-propan-2-ol; H2O / 24 h / 50 °C View Scheme
参考文献
Soellner, Matthew B.; Rawls, Katherine A.; Grundner, Christoph; Alber, Tom; Ellman, Jonathan A.
Journal of the American Chemical Society, 2007 , vol. 129, # 31 p. 9613 - 9615
反应条件
7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene on polystyrene.HL in acetonitrile T=80°C; Esterification;
参考文献
Boisnard, Sabine; Chastanet, Jaqueline; Zhu, Jieping
Tetrahedron Letters, 1999 , vol. 40, # 42 p. 7469 - 7472
反应条件
cesium fluoride in acetonitrile 22 h; Ambient temperature;
参考文献
Zhu, Jieping; Bigot, Antony; Elise, Marie; Dau, Tran Huu
Tetrahedron Letters, 1997 , vol. 38, # 7 p. 1181 - 1182
反应条件
dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; tripotassium phosphate monohydrate; palladium diacetate in toluene Suzuki coupling;
参考文献
O'Connell, Daniel P.; Leblanc, Daniel F.; Cromley, Debra; Billheimer, Jeffrey; Rader, Daniel J.; Bachovchin, William W.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 3 p. 1397 - 1401
反应条件
in acetonitrile 24 h; Heating;
参考文献
Synthesis, , # 12 p. 1145 - 1147
反应条件
sodium carbonate; bis(dibenzylideneacetone)-palladium(0); dicyclohexyl(2',6'-diisopropoxy-[1,1'-biphenyl]-2-yl)phosphine in 1,4-dioxane; water Suzuki-Miyaura cross-coupling; 10 h; Inert atmosphereReflux;
参考文献
Murai, Norio; Yonaga, Masahiro; Tanaka, Keigo
Organic Letters, 2012 , vol. 14, # 5 p. 1278 - 1281
反应条件
1.1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; tripotassium phosphate monohydrate; palladium diacetate / toluene 2.1: 10 palladium on activated charcoal; hydrogen / ethanol 3.1: hydrogenchloride; sodium nitrite / water / Cooling with ice 4.1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; triethylamine / 1,4-dioxane / 80 °C 5.1: potassium hydrogen fluoride / methanol; water / 0.5 h 5.2: 1 h View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 3 p. 1397 - 1401
