1: 60 percent / BF3-Et2O / toluene / 0.5 h / -78 °C 2: 76 percent / aq. HCl / acetonitrile / 20 °C View Scheme

1: 73 percent / diethyl ether; tetrahydrofuran / 2 h / 0 °C 2: 65 percent / 2 h / Heating View Scheme

1: 1-[(4-methylphenyl)sulfinyl]-2-(trimethylsilyl)ethane With lithium diisopropyl amide in tetrahydrofuran T=0°C; 0.25 h; 2: (E)-N-(2,2,2-trifluoroethylidene)-4-methoxyaniline in tetrahydrofuran T=-78 - 20°C; Further stages.;

in tetrahydrofuran; diethyl ether T=0°C; 2 h;

chloro-trimethyl-silane; zinc in tetrahydrofuran Barbier-type reaction; 0.5 h; RefluxInert atmosphere;

1: With L-proline in 1-methyl-pyrrolidin-2-one T=-20 - 0°C; cross-Mannich reaction; 2: With sodium tetrahydroborate in methanol T=0°C; 3 h; Further byproducts given;