2-(3-溴苯基)-1,3-二氧烷合成路线 （共 39 条）
反应条件
hydrogenchloride multistep reaction; various catalysts; Product distribution;
参考文献
Bebon-Rampal, C.; Vanhove, D.
Bulletin de la Societe Chimique de France, 1992 , # 5 p. 501 - 508
反应条件
1: 1) Mg, I2 / 2) Pd(PPh3)4 / 1) THF, reflux, 2 h, 2) THF, reflux, 2 h 2: aq. HCl / tetrahydrofuran / 10 h / Ambient temperature View Scheme
参考文献
Zhuang, Yan; Hartmann, Rolf W.
Archiv der Pharmazie, 1999 , vol. 332, # 1 p. 25 - 30
反应条件
triethylamine; tetrakis(triphenylphosphine) palladium(0) T=95°C; Substitution; Phosphorylation; 12 h;
参考文献
Caplan, Neil A.; Pogson, Christopher I.; Hayes, David J.; Blackburn, G. Michael
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 3 p. 421 - 437
反应条件
1: With n-butyllithium in tetrahydrofuran T=-78°C; 0.166667 h; Inert atmosphere; 2: With tri-isopropoxy-borane in tetrahydrofuran T=-78 - 20°C; 1 h; Inert atmosphere; 3: With hydrogenchloride; water; sodium chloride in tetrahydrofuran 0.5 h;
参考文献
Molander, Gary A.; Trice, Sarah L. J.; Kennedy, Steven M.
Organic Letters, 2012 , vol. 14, # 18 p. 4814 - 4817,4
反应条件
1: 2-(3-bromo-phenyl)-[1,3]-dioxolane With diisobutyl-aluminum chloride in tetrahydrofuran T=-78°C; Inert atmosphereSchlenk technique; 2: With n-butyllithium in tetrahydrofuran; hexane T=-78 - 20°C; Inert atmosphereSchlenk technique; 3: cyclohexane carboxylic acid chloride With CuCN*2LiCl in tetrahydrofuran; hexane T=-40 - 25°C; Inert atmosphere;
参考文献
Klatt, Thomas; Groll, Klaus; Knochel, Paul
Chemical Communications, 2013 , vol. 49, # 62 p. 6953 - 6955
反应条件
1: tris-(dibenzylideneacetone)dipalladium(0) / toluene 2: hydrogenchloride / tetrahydrofuran / 0 - 20 °C / |Inert atmosphere View Scheme
参考文献
ENVIVO PHARMACEUTICALS, INC.; RIPKA, Amy; SHAPIRO, Gideon; MCRINER, Andrew, J.; BURSAVICH, Matthew, Gregory
Patent: WO2013/142269 A1, 2013 ;
反应条件
hydrogenchloride multistep reaction; various catalysts; Product distribution;
参考文献
Bebon-Rampal, C.; Vanhove, D.
Bulletin de la Societe Chimique de France, 1992 , # 5 p. 501 - 508
反应条件
1: 1.) Mg, 2.) (Ph3P)2NiCl2 / 2.) Et2O, 3 d 2: 1N HCl / toluene / 0.17 h View Scheme
参考文献
Hashizume, Hirokazu; Ito, Hajime; Kanaya, Naoaki; Nagashima, Hajime; Usui, Hiroyuki; et al.
Heterocycles, 1994 , vol. 38, # 7 p. 1551 - 1572
反应条件
tris(dibenzylideneacetone)dipalladium (0); lithium hexamethyldisilazane; 2-dicyclohexylphosphino-1,1'-biphenyl in tetrahydrofuran T=65°C; 15 h;
参考文献
Huang; Buchwald
Organic letters, 2001 , vol. 3, # 21 p. 3417 - 3419
反应条件
dihydrogen peroxide; vanadium pentoxide in water T=5°C; 6 h;
参考文献
Tetrahedron Letters, , vol. 43, # 29 p. 5123 - 5126
