(3-丙羧基)三苯基溴化膦合成路线 （共 19 条）
反应条件
in toluene 48 h; Inert atmosphereReflux;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 19, # 1 p. 567 - 579
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 45, # 4 p. 685 - 696
参考文献
Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), , p. 1739 - 1746
反应条件
1.1: t-BuOK / dimethylsulfoxide / 0.33 h / 20 °C 1.2: 78 percent / dimethylsulfoxide / 4 h / 20 °C 2.1: 92 percent / H2 / PtO2 / ethanol / 2 h / 20 °C 3.1: 64 percent / polyphosphoric acid / 1 h / 130 °C View Scheme
参考文献
Ruiu, Stefania; Pinna, Gerard A.; Marchese, Giorgio; Mussinu, Jean-Mario; Saba, Pierluigi; Tambaro, Simone; Casti, Paola; Vargiu, Romina; Pani, Luca
Journal of Pharmacology and Experimental Therapeutics, 2003 , vol. 306, # 1 p. 363 - 370
反应条件
1.1: potassium tert-butylate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere 1.2: 12 h / 20 °C 2.1: hydrogen / palladium 10 on activated carbon / ethanol / 12 h 3.1: methanesulfonic acid; phosphorous pentoxide / 12 h / Inert atmosphere View Scheme
反应条件
1.1: t-BuOK / dimethylsulfoxide / 0.33 h / 20 °C 1.2: 78 percent / dimethylsulfoxide / 4 h / 20 °C 2.1: 95 percent / H2 / PtO2 / ethanol / 2 h / 20 °C 3.1: 64 percent / polyphosphoric acid / 1 h / 130 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 23 p. 7351 - 7362
反应条件
dimsyl sodium; sodium carbonate
1.) 23 deg C, 20 min, 2.) 23 deg C, 4 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Kluge, Arthur F.; Kertesz, Denis J.; O-Yang, Counde; Wu, Helen Y.
Journal of Organic Chemistry, 1987 , vol. 52, # 13 p. 2860 - 2868
反应条件
1.1: potassium tert-butylate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
1.2: 12 h / 20 °C
2.1: hydrogen / palladium 10 on activated carbon / ethanol / 12 h
View Scheme
参考文献
Tanpure, Rajendra P.; George, Clinton S.; Sriram, Madhavi; Strecker, Tracy E.; Tidmore, Justin K.; Hamel, Ernest; Charlton-Sevcik, Amanda K.; Chaplin, David J.; Trawick, Mary Lynn; Pinney, Kevin G.
MedChemComm, 2012 , vol. 3, # 6 p. 720 - 724
反应条件
n-butyllithium in tetrahydrofuran; dimethyl sulfoxide
参考文献
Carballeira; Emiliano; Hernandez-Alonso; Gonzalez
Journal of Natural Products, 1998 , vol. 61, # 12 p. 1543 - 1546
反应条件
1.1: potassium tert-butylate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
1.2: 12 h / 20 °C
2.1: hydrogen / palladium 10 on activated carbon / ethanol / 12 h
3.1: methanesulfonic acid; phosphorous pentoxide / 12 h / Inert atmosphere
4.1: nitric acid; acetic anhydride / acetic acid / 3 h / -78 °C
View Scheme
参考文献
BAYLOR UNIVERSITY
Patent: US2012/130129 A1, 2012 ;
