6-氨基-3-溴吡啶-2-甲酸甲酯合成路线 （共 13 条）
反应条件
bromine in chloroform
参考文献
Journal of Organic Chemistry, , vol. 61, # 14 p. 4623 - 4633
反应条件
1: With bromine; sodium carbonate; acetic acid T=10 - 35°C; 7 h; 2: With sodium hydrogencarbonate in water; ethyl acetate
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP2098513 A1, 2009 ;
Location in patent: Page/Page column 49 ;
EP 2098513 A1
反应条件
bromine in chloroform T=20°C;
参考文献
WO2011/75591 A1, ;
Page/Page column 95 ;
反应条件
in methanol; hexane; ethyl acetate 72 h;
参考文献
US2013/96120 A1, ;
Paragraph 1079 ;
反应条件
1: 100 percent / 1.5 h / 60 - 70 °C 2: 16.5 g / KMnO4 / H2O / 3 h / 75 °C 3: HCl / Heating 4: 25 percent / Br2 / CHCl3 View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 14 p. 4623 - 4633
反应条件
1: 16.5 g / KMnO4 / H2O / 3 h / 75 °C 2: HCl / Heating 3: 25 percent / Br2 / CHCl3 View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 14 p. 4623 - 4633
反应条件
1: HCl / Heating 2: 25 percent / Br2 / CHCl3 View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 14 p. 4623 - 4633
反应条件
1.1: 1.5 h / 90 °C 2.1: water; potassium permanganate / 4 h / 75 °C 2.2: pH 4 - 5 3.1: hydrogenchloride / methanol / 18 h / Reflux 4.1: bromine / chloroform / 40 h / 20 °C View Scheme
反应条件
1.1: water; potassium permanganate / 4 h / 75 °C 1.2: pH 4 - 5 2.1: hydrogenchloride / methanol / 18 h / Reflux 3.1: bromine / chloroform / 40 h / 20 °C View Scheme
反应条件
1: hydrogenchloride / methanol / 18 h / Reflux 2: bromine / chloroform / 40 h / 20 °C View Scheme
参考文献
US2011/201605 A1, ;
WO2011/101304 A2, ;
WO 2011/101304 A2
