1-苯并噻吩-2-羧酸乙酯合成路线 （共 28 条）
反应条件
1: mercapto acetic acid ethylester With sodium hydride in N,N-dimethyl-formamide
T=20°C; 0.5 h;
2: ortho-fluorobenzaldehyde in N,N-dimethyl-formamide
18 h; Reflux;
参考文献
Matthews, Jay M.; Qin, Ning; Colburn, Raymond W.; Dax, Scott L.; Hawkins, Mike; McNally, James J.; Reany, Laura; Youngman, Mark A.; Baker, Judith; Hutchinson, Tasha; Liu, Yi; Lubin, Mary Lou; Neeper, Michael; Brandt, Michael R.; Stone, Dennis J.; Flores, Christopher M.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 8 p. 2922 - 2926
反应条件
potassium carbonate in N,N-dimethyl-formamide
1.) 0 deg C, 30 min, 2.) RT, 24 h;
参考文献
Guo, Hui-Fang; Shao, Hua-Yi; Yang, Zhao-Yong; Xue, Si-Tu; Li, Xue; Liu, Zong-Ying; He, Xiao-Bo; Jiang, Jian-Dong; Zhang, Yue-Qin; Si, Shu-Yi; Li, Zhuo-Rong
Journal of Medicinal Chemistry, 2010 , vol. 53, # 4 p. 1819 - 1829
反应条件
sodium carbonate in N,N,N',N',N'',N''-hexamethylphosphoric triamide
T=80°C; 8 h;
参考文献
Rahman, Loay K. A.; Scrowston, Richard M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 3 p. 385 - 390
反应条件
[2,2']bipyridinyl; palladium (II) trifluoroacetate in nitromethane
T=120°C; 48 h; Inert atmosphere;
参考文献
Qian, Cheng; Chen, Jiayan; Fu, Meiqin; Zhu, Shiya; Chen, Wen-Hua; Jiang, Huanfeng; Zeng, Wei
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 36 p. 6013 - 6022
反应条件
potassium tert-butylate in ammonia
180 h; Irradiation;
参考文献
Beugelmans, Rene; Bois-Choussy, Michele; Boudet, Bernard
Tetrahedron, 1983 , vol. 39, # 24 p. 4153 - 4162
反应条件
1.1: tris-(dibenzylideneacetone)dipalladium(0); 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene / toluene / 0.03 h / Inert atmosphere
1.2: 0.75 h / 130 °C / Inert atmosphere; Microwave irradiation
2.1: caesium carbonate / toluene / 0.25 h / 130 °C / Inert atmosphere; Microwave irradiation
View Scheme
参考文献
Guilarte, Veronica; Fernandez-Rodriguez, Manuel A.; Garcia-Garcia, Patricia; Hernando, Elsa; Sanz, Roberto
Organic Letters, 2011 , vol. 13, # 19 p. 5100 - 5103
反应条件
1.1: copper(l) iodide; Pd2(PPh3)2Cl2; diethylamine / 20 °C / Inert atmosphere
2.1: tris-(dibenzylideneacetone)dipalladium(0); 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene / toluene / 0.03 h / Inert atmosphere
2.2: 0.75 h / 130 °C / Inert atmosphere; Microwave irradiation
3.1: caesium carbonate / toluene / 0.25 h / 130 °C / Inert atmosphere; Microwave irradiation
View Scheme
参考文献
Guilarte, Veronica; Fernandez-Rodriguez, Manuel A.; Garcia-Garcia, Patricia; Hernando, Elsa; Sanz, Roberto
Organic Letters, 2011 , vol. 13, # 19 p. 5100 - 5103
反应条件
1.1: copper(l) iodide; Pd2(PPh3)2Cl2; diethylamine / 20 °C / Inert atmosphere
2.1: tris-(dibenzylideneacetone)dipalladium(0); 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene / toluene / 0.03 h / Inert atmosphere
2.2: 0.75 h / 130 °C / Inert atmosphere; Microwave irradiation
3.1: caesium carbonate / toluene / 0.25 h / 130 °C / Inert atmosphere; Microwave irradiation
View Scheme
参考文献
Guilarte, Veronica; Fernandez-Rodriguez, Manuel A.; Garcia-Garcia, Patricia; Hernando, Elsa; Sanz, Roberto
Organic Letters, 2011 , vol. 13, # 19 p. 5100 - 5103
反应条件
1: hydrofluoroboric acid; sodium nitrite / water / 0.67 h / 0 - 5 °C
2: Eosin / dimethyl sulfoxide / 14 h / 20 °C / |Irradiation
View Scheme
参考文献
Hari, Durga Prasad; Hering, Thea; Koenig, Burkhard
Organic Letters, 2012 , vol. 14, # 20 p. 5334 - 5337,4
反应条件
1.1: potassium hydroxide / water / 17 h / |Reflux
1.2: 1 h / 20 °C
2.1: hydrofluoroboric acid; sodium nitrite / water / 0.67 h / 0 - 5 °C
3.1: Eosin / dimethyl sulfoxide / 14 h / 20 °C / |Irradiation
View Scheme
参考文献
Hari, Durga Prasad; Hering, Thea; Koenig, Burkhard
Organic Letters, 2012 , vol. 14, # 20 p. 5334 - 5337,4
