6-甲氧基-7-苄氧基喹唑啉-4-酮合成路线 （共 34 条）
反应条件
sodium acetate; acetic acid in 1,4-dioxane 24 h; Heating / reflux;
参考文献
Astrazeneca AB
Patent: US6593333 B1, 2003 ;
US 6593333 B1
反应条件
1: in 1,4-dioxane 12 h; Reflux; 2: With sodium acetate; acetic acid in 1,4-dioxane 3 h; Reflux;
参考文献
HANMI HOLDINGS CO., LTD.; BAE, In Hwan; BYUN, Eun Young; JU, Hae Kyoung; SONG, Ji Young; JUNG, Seung Hyun; JUN, Mi Ae; KIM, Ho Seok; JUNG, Young Hee; SHIM, Mi Yon; AHN, Young Gil; KIM, Maeng Sup
Patent: WO2012/30160 A2, 2012 ;
Location in patent: Page/Page column 51 ;
反应条件
ammonium formate T=180 - 190°C; 2 h;
参考文献
Qian, Changgeng; Cai, Xiong; Zhai, Haixiao
Patent: US2009/76044 A1, 2009 ;
Location in patent: Page/Page column 27 ;
US 20090076044 A1
反应条件
1: 2-amino-4-benzyloxy-5-methoxybenzamide With Gold's reagent in 1,4-dioxane 24 h; Heating / reflux; 2: sodium acetate; acetic acid in 1,4-dioxane 3 h; Heating / reflux;
参考文献
Hennequin, Laurent Francois Andre; Stokes, Elaine Sophie Elizabeth
Patent: US2003/191308 A1, 2003 ;
Location in patent: Page/Page column 24 ;
反应条件
in 2-methyl-propan-1-ol T=97°C; 6 h; Product distribution / selectivity;
参考文献
WO2007/36713 A2, ;
Page/Page column 51; 52 ;
WO 2007/036713 A2
参考文献
Matsuno, Kenji; Ushiki, Junko; Seishi, Takashi; Ichimura, Michio; Giese, Neill A.; Yu, Jin-Chen; Takahashi, Shusuke; Oda, Shoji; Nomoto, Yuji
Journal of Medicinal Chemistry, 2003 , vol. 46, # 23 p. 4910 - 4925
反应条件
hydrogenchloride; sodium hydroxide; sodium methylate; iron; formamide in methanol; chloroform; water; acetic acid; N,N-dimethyl-formamide
反应条件
1: 2-amino-4-benzyloxy-5-methoxybenzamide With Gold's reagent in 1,4-dioxane 24 h; Heating / reflux; 2: acetic acid With sodium acetate in 1,4-dioxane 3 h;
参考文献
WO2004/4732 A1, ;
Page/Page column 67; 73 ;
WO 2004/004732 A1
反应条件
1: 100 percent / HNO3; Ac2O / 3 h / 20 °C 2: 97 percent / Fe; FeCl3 / acetic acid; H2O; ethanol / 4 h / 20 °C 3: 87 percent / 5 h / 190 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 23 p. 4910 - 4925
反应条件
1: 97 percent / Fe; FeCl3 / acetic acid; H2O; ethanol / 4 h / 20 °C 2: 87 percent / 5 h / 190 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 23 p. 4910 - 4925
