2-三正丁基甲锡烷基吡啶合成路线 （共 97 条）
反应条件
1: 75 percent / PdCl2(PPh3)2 / tetrahydrofuran / 24 h / 110 °C 2: CuSO4, NaBH4 / ethanol; H2O / 3 h / 0 °C View Scheme
参考文献
Molina; Lorenzo; Aller
Tetrahedron, 1992 , vol. 48, # 22 p. 4601 - 4616
反应条件
bis-triphenylphosphine-palladium(II) chloride in toluene 5 h; Heating / reflux;
参考文献
Eisai RandD Management Co., Ltd.
Patent: US2007/105904 A1, 2007 ;
Location in patent: Page/Page column 144 ;
反应条件
tetrakis(triphenylphosphine) palladium(0); silver(l) oxide 1) DMF, 5 min, 100 deg C, 2) DMF, 70-80 min, 100 deg C; Yield given. Multistep reaction;
参考文献
Malm, Johan; Bjoerk, Patrick; Gronowitz, Salo; Hoernfeldt, Anna-Britta
Tetrahedron Letters, 1992 , vol. 33, # 16 p. 2199 - 2202
反应条件
PdCl2(PPh2(CH2)4PPh2); copper(II) oxide in N,N-dimethyl-formamide T=100°C; 3.66667 h;
参考文献
Gronowitz, Salo; Bjoerk, Patrick; Malm, Johan; Hoernfeldt, Anna-Britta
Journal of Organometallic Chemistry, 1993 , vol. 460, # 1 p. 127 - 130
反应条件
PdCl2(PPh2(CH2)4PPh2) in N,N-dimethyl-formamide T=100°C; 24 h;
参考文献
Gronowitz, Salo; Bjoerk, Patrick; Malm, Johan; Hoernfeldt, Anna-Britta
Journal of Organometallic Chemistry, 1993 , vol. 460, # 1 p. 127 - 130
反应条件
PdCl2(PPh2(CH2)4PPh2); copper(II) oxide in N,N-dimethyl-formamide T=100°C; 3.33333 h;
参考文献
Gronowitz, Salo; Bjoerk, Patrick; Malm, Johan; Hoernfeldt, Anna-Britta
Journal of Organometallic Chemistry, 1993 , vol. 460, # 1 p. 127 - 130
反应条件
lithium chloride; bis-triphenylphosphine-palladium(II) chloride in toluene 7 h; Heating / reflux;
参考文献
EP1932851 A1, ;
Page/Page column 34 ;
反应条件
tetrakis(triphenylphosphine) palladium(0) in toluene T=110°C; Stille coupling; 24 h; Inert atmosphere;
参考文献
Chemistry - An Asian Journal, , vol. 5, # 11 p. 2405 - 2414
反应条件
1: With copper(l) iodide; triphenylphosphine; bis(dibenzylideneacetone)-palladium(0) in diethyl ether T=120°C; Stille Coupling; 4 h; Microwave irradiation; 2: With potassium fluoride; water in diethyl ether T=20°C; 3 h;
参考文献
TIBOTEC PHARMACEUTICALS LTD.; MEDIVIR AB
Patent: WO2008/96002 A1, 2008 ;
Location in patent: Page/Page column 91 ;
反应条件
tetrakis(triphenylphosphine) palladium(0); copper(I) thiophene-2-carboxylate in tetrahydrofuran T=20 - 100°C; Stille type coupling; Inert atmosphereMicrowave irradiation;
参考文献
Arshad, Nuzhat; Hashim, Jamshed; Kappe, C. Oliver
Journal of Organic Chemistry, 2009 , vol. 74, # 14 p. 5118 - 5121
