2-2,2,2-三氟萘乙酮合成路线 （共 8 条）
反应条件
1-methyl-pyrrolidin-2-one; tributylphosphine; palladium diacetate T=80°C; 4 h;
参考文献
Schenck, Hilary A.; Lenkowski, Paul W.; Choudhury-Mukherjee, Indrani; Ko, Seong-Hoon; Stables, James P.; Patel, Manoj K.; Brown, Milton L.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 5 p. 979 - 993
反应条件
boron trifluoride diethyl etherate in diethyl ether T=-78°C; 1.5 h;
参考文献
Ramachandran, P. Veeraraghavan; Teodorovic, Aleksandar V.; Brown, Herbert C.
Tetrahedron, 1993 , vol. 49, # 9 p. 1725 - 1738
反应条件
aluminium trichloride in dichloromethane T=0°C; 4 h; Yield given. Yields of byproduct given;
参考文献
Keumi, Takashi; Shimada, Masakazu; Takahashi, Masahiro; Kitajima, Hidehiko
Chemistry Letters, 1990 , # 5 p. 783 - 786
反应条件
1: 2-bromo-naphthalene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 2 h; 2: N-(trifluoroacetyl)piperidine in tetrahydrofuran; hexane T=-78 - 20°C; 3 h;
参考文献
Dong, Kaiwu; Li, Yang; Wang, Zheng; Ding, Kuiling
Angewandte Chemie - International Edition, 2013 , vol. 52, # 52 p. 14191 - 14195
Angew. Chem., 2013 , vol. 125, # 52 p. 14441 - 14445,5
反应条件
1.1: magnesium; I2; dibromoethane 1.2: 87 percent / tetrahydrofuran; toluene / 1 h / -78 °C 2.1: 99 percent / KOH / ethanol / 20 °C 3.1: 90 percent / Co(III) o-phenylene-bis(N'-methyloxamidate) complex; O2; pivalaldehyde / CH2Cl2 View Scheme
参考文献
Blay, Gonzalo; Fernandez, Isabel; Marco-Aleixandre, Alicia; Monje, Belen; Pedro, Jose R; Ruiz, Rafael
Tetrahedron, 2002 , vol. 58, # 42 p. 8565 - 8571
反应条件
1: 99 percent / KOH / ethanol / 20 °C 2: 90 percent / Co(III) o-phenylene-bis(N'-methyloxamidate) complex; O2; pivalaldehyde / CH2Cl2 View Scheme
参考文献
Blay, Gonzalo; Fernandez, Isabel; Marco-Aleixandre, Alicia; Monje, Belen; Pedro, Jose R; Ruiz, Rafael
Tetrahedron, 2002 , vol. 58, # 42 p. 8565 - 8571
反应条件
n-butyllithium in tetrahydrofuran
参考文献
Gaspar, Jordi; Guerrero, Angel
Tetrahedron: Asymmetry, 1995 , vol. 6, # 1 p. 231 - 238
反应条件
(i) Mg, MeI, Et2O, (ii) /BRN= 742035/; Multistep reaction;
参考文献
Stewart,R.; Lee,D.G.
Canadian Journal of Chemistry, 1964 , vol. 42, p. 439 - 446
