3-(吡啶-3-基)丙醛合成路线 （共 10 条）
反应条件
ammonium cerium (IV) nitrate; MacMillan imidazolidinone in ethylene glycol dimethyl ether T=25°C; 2 h;
参考文献
Zhu, Jin; Yu, Shunting; Lu, Wenchao; Deng, Jing; Li, Jian; Wang, Wei
Tetrahedron Letters, 2012 , vol. 53, # 10 p. 1207 - 1209
反应条件
Dess-Martin periodane
参考文献
Yamada, Akihiro; Kitamura, Hitomi; Yamaguchi, Kaori; Fukuzawa, Seketsu; Kamijima, Chiyuki; Yazawa, Kazunaga; Kuramoto, Makoto; Wang, Gui-Yang-Sheng; Fujitani, Yasuyuki; Uemura, Daisuke
Bulletin of the Chemical Society of Japan, 1997 , vol. 70, # 12 p. 3061 - 3069
反应条件
triethylamine in dichloromethane; water
参考文献
Pfizer Inc.
Patent: US5744488 A1, 1998 ;
反应条件
diisobutylaluminium hydride in toluene
T=-78°C; 2 h;
参考文献
Voelker, Troy; Xia, Haiji; Fandrick, Keith; Johnson, Robert; Janowsky, Aaron; Cashman, John R.
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 5 p. 2047 - 2068
反应条件
hydrogenchloride; sodium hydroxide in palladium monocarbide; ethyl acetate; benzene
参考文献
Bold, Guido; Dawson King, Janet; Frei, Jorg; Heng, Richard; Manley, Paul William; Wietfeld, Bernhard; Wood, Jeanette Marjorie
Patent: US2003/13718 A1, 2003 ;
反应条件
in dichloromethane; sodium hydrogencarbonate
参考文献
Vertex Pharmaceuticals Incorporated
Patent: US5620971 A1, 1997 ;
US 5620971 A
反应条件
N,N-dicyclohexylmethylamine; potassium carbonate; bis(dibenzylideneacetone)-palladium(0); cataCXium PIntB in N,N-dimethyl-formamide
T=100°C; 0.5 h; Molecular sieveInert atmosphere;
参考文献
Colbon, Paul; Ruan, Jiwu; Purdie, Mark; Mulholland, Keith; Xiao, Jianliang
Organic Letters, 2011 , vol. 13, # 20 p. 5456 - 5459
反应条件
hydrogen; dodecacarbonyltetrarhodium(0); (dimethyl)(phenyl)phosphine in benzene
T=100°C; Hydroformylation; P=83600 Torr; 3.33333 h; Product distribution; Further Variations:CatalystsTemperatures;
参考文献
Caiazzo, Aldo; Settambolo, Roberta; Pontorno, Lorenzo; Lazzaroni, Raffaello
Journal of Organometallic Chemistry, 2000 , vol. 599, # 2 p. 298 - 303
反应条件
sulfuric acid in tetrahydrofuran; diethyl ether
参考文献
Dainippon Pharmaceutical Company, Limited
Patent: US6555557 B1, 2003 ;
反应条件
1: 17 g / ammonium chloride / diethyl ether; H2O / 1.) 0 deg C, 4 h; 2.) 50 deg C, 7.5 h
2: 12M aq. hydrochloric acid / 1.) 64 h, room temperature; 2.) 30 h, reflux temperature
View Scheme
参考文献
Ratcliffe, Steven J.; Young, Geoffrey T.; Stein, Ross L.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 1767 - 1772
