5,6,7,8-四氢-4H-噻吩并[3,2-b]氮杂合成路线 （共 8 条）
反应条件
aluminum dichloride hydride in CPME T=0 - 20°C; 3 h;
参考文献
Cho, Hidetsura; Iwama, Yusuke; Mitsuhashi, Nakako; Sugimoto, Kenji; Okano, Kentaro; Tokuyama, Hidetoshi
Molecules, 2012 , vol. 17, # 6 p. 7348 - 7355
反应条件
sodium hydroxide in tetrahydrofuran; methanol
参考文献
American Cyanamid Company
Patent: US5654297 A1, 1997 ;
US 5654297 A
反应条件
dimethylsulfide borane complex in tetrahydrofuran Reduction;
参考文献
Albright, J. Donald; Santos, Efren G. Delos; Dusza, John P.; Chan, Peter S.; Coupet, Joseph; Ru, Xun; Mazandarani
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 8 p. 695 - 698
反应条件
diisobutylaluminium hydride in dichloromethane T=25°C; 2 h;
参考文献
Cho, Hidetsura; Murakami, Kengo; Nakanishi, Hiroyuki; Isoshima, Hirotaka; Hayakawa, Kazuhide; Uchida, Itsuo
Heterocycles, 1998 , vol. 48, # 5 p. 919 - 927
反应条件
1: 99 percent / NH2OH*HCl; aq. NaOAc / ethanol 2: 92 percent / pyridine 3: 60 percent / aq. KOAc / ethanol 4: 91 percent / BH3*S(CH3)2 / tetrahydrofuran View Scheme
参考文献
Cho, Hidetsura; Murakami, Kengo; Nakanishi, Hiroyuki; Isoshima, Hirotaka; Hayakawa, Kazuhide; Uchida, Itsuo
Heterocycles, 1998 , vol. 48, # 5 p. 919 - 927
反应条件
1: 60 percent / aq. KOAc / ethanol 2: 91 percent / BH3*S(CH3)2 / tetrahydrofuran View Scheme
参考文献
Albright, J. Donald; Santos, Efren G. Delos; Dusza, John P.; Chan, Peter S.; Coupet, Joseph; Ru, Xun; Mazandarani
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 8 p. 695 - 698
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 3 h; Heating;
参考文献
Cho, Hidetsura; Murakami, Kengo; Nakanishi, Hiroyuki; Isoshima, Hirotaka; Hayakawa, Kazuhide; Uchida, Itsuo
Heterocycles, 1998 , vol. 48, # 5 p. 919 - 927
反应条件
1: 1.) potassium hydride; 2.) aq. DMSO / 1.) PhMe; 2.) 150 deg C 2: lithium aluminum hydride / tetrahydrofuran / 3 h / Heating View Scheme
参考文献
Cho, Hidetsura; Murakami, Kengo; Nakanishi, Hiroyuki; Isoshima, Hirotaka; Hayakawa, Kazuhide; Uchida, Itsuo
Heterocycles, 1998 , vol. 48, # 5 p. 919 - 927
