1-N-Boc-4-(2-叔丁氧基-2-氧代乙基)哌嗪合成路线 （共 2 条）
反应条件
triethylamine in tetrahydrofuran T=20°C; 12 h;
参考文献
Sequoia Sciences, Inc.; Eldridge, Gary R.; Buckle, Ronald Neil; Ellis, Michael; Huang, Zhongping; Reilly, John Edward
Patent: EP2712863 A1, 2014 ;
Location in patent: Paragraph 0611; 0612 ;
反应条件
1: acetic acid tert-butyl ester With Zn(2,2,6,6-tetramethylpiperidide)2 in toluene T=20°C; 1 h; Microwave irradiation; 2: tert-butyl 4-(benzoyloxy)piperazine-1-carboxylate With [2,2']bipyridinyl; copper dichloride in tetrahydrofuran; toluene T=20°C; 1 h; Microwave irradiation;
参考文献
McDonald, Stacey L.; Wang, Qiu
Chemical Communications, 2014 , vol. 50, # 19 p. 2535 - 2538
