7-甲基-1H-吲哚-5-羧酸甲酯合成路线 （共 9 条）
反应条件
dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; potassium phosphate; palladium diacetate in toluene T=100°C; 3 h;
参考文献
US2012/58986 A1, ;
Page/Page column 33 ;
US 20120058986 A1
反应条件
copper(l) iodide in N,N-dimethyl-formamide T=100°C; Cyclization; 2.5 h;
参考文献
Ezquerra, Jesus; Pedregal, Concepcion; Lamas, Carlos; Barluenga, Jose; Perez, Marta; Garcia-Martin, Miguel Angel; Gonzalez, Jose M.
Journal of Organic Chemistry, 1996 , vol. 61, # 17 p. 5804 - 5812
反应条件
1: 3-Methyl-4-nitrobenzoic acid With caesium carbonate; Merrifield resin in N,N-dimethyl-formamide T=50°C; 24 h; 2: vinyl-magnesium bromide in tetrahydrofuran T=-40 - 0°C; Bartoli reaction; 3: methanol With sodium methylate in tetrahydrofuran T=25°C; 3 h;
参考文献
Organic Letters, , vol. 5, # 16 p. 2829 - 2832
反应条件
1: SOCl2 / 2 h / 20 °C 2: 99 percent / bis(pyridine)iodonium(I) tetrafluoroborate; CF3SO3H / CH2Cl2 / 16 h / 20 °C 3: 90 percent / Et3N / Pd(PPh3)2Cl2-CuI / 3 h / 0 - 20 °C 4: 60 percent / CuI / dimethylformamide / 2.5 h / 100 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 17 p. 5804 - 5812
反应条件
1: 99 percent / bis(pyridine)iodonium(I) tetrafluoroborate; CF3SO3H / CH2Cl2 / 16 h / 20 °C 2: 90 percent / Et3N / Pd(PPh3)2Cl2-CuI / 3 h / 0 - 20 °C 3: 60 percent / CuI / dimethylformamide / 2.5 h / 100 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 17 p. 5804 - 5812
反应条件
1: 90 percent / Et3N / Pd(PPh3)2Cl2-CuI / 3 h / 0 - 20 °C 2: 60 percent / CuI / dimethylformamide / 2.5 h / 100 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 17 p. 5804 - 5812
反应条件
in tetrahydrofuran; methanol T=25°C; 3 h; solid phase reaction;
参考文献
Knepper, Kerstin; Vanderheiden, Sylvia; Braese, Stefan
Beilstein Journal of Organic Chemistry, 2012 , vol. 8, p. 1191 - 1199
反应条件
potassium hydroxide; water in ethanol Hydrolysis; 24 h; Heating;
参考文献
Ezquerra, Jesus; Pedregal, Concepcion; Lamas, Carlos; Barluenga, Jose; Perez, Marta; Garcia-Martin, Miguel Angel; Gonzalez, Jose M.
Journal of Organic Chemistry, 1996 , vol. 61, # 17 p. 5804 - 5812
反应条件
1: 96 percent / KOH; H2O / ethanol / 24 h / Heating 2: 50 percent / Cu2O / quinoline / 4 h / 230 °C View Scheme
参考文献
Ezquerra, Jesus; Pedregal, Concepcion; Lamas, Carlos; Barluenga, Jose; Perez, Marta; Garcia-Martin, Miguel Angel; Gonzalez, Jose M.
Journal of Organic Chemistry, 1996 , vol. 61, # 17 p. 5804 - 5812
