1-羟基-3H-吲哚-2-酮合成路线 （共 19 条）
反应条件
sodium hydroxide; water; dihydrogen peroxide
Behandeln der Reaktionsloesung mit wss.Schwefelsaeure und Zink-Pulver;
参考文献
Wright; Collins
Journal of the American Chemical Society, 1956 , vol. 78, p. 221,222
反应条件
in sulfuric acid; sodium carbonate
参考文献
LUXEMBOURG BIO TECHNOLOGIES LTD.
Patent: US2010/144588 A1, 2010 ;
反应条件
sulfuric acid in methanol
5 h;
参考文献
Guilbaud-Criqui, A.; Moinet, C.
Bulletin de la Societe Chimique de France, 1993 , vol. 130, # 2 p. 164 - 172
反应条件
sulfuric acid; zinc
T=30°C;
参考文献
Reissert
Chemische Berichte, 1908 , vol. 41, p. 3925
参考文献
Somei, Masanori; Sato, Haruhiko; Kaneko, Chikara
Heterocycles, 1983 , vol. 20, # 9 p. 1797 - 1799
反应条件
aluminium trichloride; ethanethiol
75 h; Ambient temperature;
参考文献
Kawase, Masami; Kitamura, Takahiro; Shimada, Masahiro; Kikugawa, Yasuo
Synthetic Communications, 1990 , vol. 20, # 6 p. 887 - 892
反应条件
1: ethanolic sodium ethylate / Erhitzen des Reaktionsgemisches mit Wasser
2: aq. NaOH solution; aqueous hydrogen peroxide
3: platinum; acetic acid / Hydrogenation
View Scheme
参考文献
Di Carlo
Journal of the American Chemical Society, 1944 , vol. 66, p. 1420
反应条件
Clostridium perfringens; brain heart infusion medium#10; in dimethyl sulfoxide
T=37°C; pH=7.4; 24 h; Enzymatic reaction;
参考文献
Marquez Ruiz, Juan F.; Kedziora, Kinga; Pigott, Maria; Keogh, Brian; Windle, Henry; Gavin, Jason; Kelleher, Dermot P.; Gilmer, John F.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 6 p. 1693 - 1698
反应条件
1: 95 percent / PPh3, diethyl diazocarbonate / CHCl3 / 1 h
2: 88.2 percent / DIBAL / toluene; tetrahydrofuran / 1 h / -78 °C
3: 86.9 percent / POCl3 / 3 h / Ambient temperature
4: 84 percent / BF3*Et2O / acetonitrile / 1 h / Ambient temperature
View Scheme
参考文献
Henmi, Toshiyuki; Sakamoto, Takeshi; Kikugawa, Yasuo
Heterocycles, 1997 , vol. 44, # 1 p. 157 - 163
