N-[2-(4-溴苯基)乙基]-2,2,2-三氟乙酰胺合成路线 （共 8 条）
参考文献
ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA
Patent: WO2004/87714 A1, 2004 ;
Location in patent: Page 71 ;
WO 2004/087714 A1
反应条件
pyridine in dichloromethane T=0 - 20°C; 48 h;
参考文献
Butora, Gabor; Goble, Stephen D.; Pastemak, Alexander; Yang, Lihu; Zhou, Changyou; Moyes, Christopher R.
Patent: US2008/81803 A1, 2008 ;
Location in patent: Page/Page column 34 ;
US 20080081803 A1
反应条件
2,6-dimethylpyridine in dichloromethane T=0 - 20°C; 16 h;
参考文献
ASTRAZENECA AB
Patent: WO2004/60882 A1, 2004 ;
Location in patent: Page 35 ;
WO 2004/060882 A1
反应条件
1: in sulfuric acid; acetic acid T=20°C; 17 h; 2: With potassium carbonate in ethanol; water 1 h; Heating / reflux;
参考文献
MERCK and CO., INC.; MERCK SHARP and DOHME LIMITED
Patent: WO2004/94371 A2, 2004 ;
Location in patent: Page 81 ;
WO 2004/094371 A2
反应条件
formaldehyd; sulfuric acid in water T=20°C; 18 h;
参考文献
NOVARTIS AG
Patent: WO2008/76954 A2, 2008 ;
Location in patent: Page/Page column 51 ;
WO 2008/076954 A2
反应条件
sulfuric acid; acetic acid T=20°C;
参考文献
ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA
Patent: WO2004/87714 A1, 2004 ;
Location in patent: Page 71 ;
WO 2004/087714 A1
反应条件
sulfuric acid in acetic acid T=20°C; 16 h;
参考文献
Stokker
Tetrahedron Letters, 1996 , vol. 37, # 31 p. 5453 - 5456
反应条件
sulfuric acid; acetic acid T=20°C; 20 h;
参考文献
ASTRAZENECA AB
Patent: WO2004/60882 A1, 2004 ;
Location in patent: Page 36 ;
WO 2004/060882 A1
