1,4-双(N-Boc)哌嗪-2-甲酸合成路线 （共 14 条）
反应条件
1: With sodium hydroxide in 1,4-dioxane; water T=5°C; 24 h; 2: With hydrogenchloride; water in 1,4-dioxane T=5°C; pH=3;
参考文献
GLAXO GROUP LIMITED
Patent: WO2008/148853 A1, 2008 ;
Location in patent: Page/Page column 157-158 ;
WO 2008/148853 A1
反应条件
1: With sodium hydroxide in 1,4-dioxane; water T=0 - 25°C; 3.5 h; 2: With hydrogenchloride in 1,4-dioxane; water pH=6 - 7;
参考文献
TORRENT PHARMACEUTICALS LTD.
Patent: US2004/106802 A1, 2004 ;
Location in patent: Page 35 ;
反应条件
acetic acid in 1,4-dioxane; water
参考文献
Merck Sharp and Dohme Ltd.
Patent: US5849746 A1, 1998 ;
反应条件
sodium hydroxide in methanol
反应条件
triethylamine in 1,4-dioxane; water T=20°C;
参考文献
Catalano, Alessia; Carocci, Alessia; Corbo, Filomena; Franchini, Carlo; Muraglia, Marilena; Scilimati, Antonio; De Bellis, Michela; De Luca, Annamaria; Camerino, Diana Conte; Sinicropi, Maria Stefania; Tortorella, Vincenzo
European Journal of Medicinal Chemistry, 2008 , vol. 43, # 11 p. 2535 - 2540
参考文献
US2011/82114 A1, ;
US 20110082114 A1
反应条件
1: With triethylamine in tetrahydrofuran T=-10°C; 1 h; 2: With sodium tetrahydroborate in tetrahydrofuran; water T=-10°C; 1 h; 3: With hydrogenchloride in tetrahydrofuran; water; ethyl acetate
参考文献
Matsumoto, Takahiro; Kamo, Izumi; Nomura, Izumi
Patent: US2009/318412 A1, 2009 ;
Location in patent: Page/Page column 34 ;
US 20090318412 A1
反应条件
borane-THF in tetrahydrofuran T=50°C; 2 h;
参考文献
Clark, Roger B.; Elbaum, Daniel
Tetrahedron, 2007 , vol. 63, # 14 p. 3057 - 3065
反应条件
in tetrahydrofuran; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; water
参考文献
Agejas-Chicharro, Javier; Belen Bueno Melendo, Ana; Camp, Nicholas Paul; Gilmore, Jeremy; Jimenez-Aguado, Alma Maria; Lamas-Peteira, Carlos; Marcos-Llorente, Alicia; Mazanetz, Michael Philip; Montero Salgado, Carlos; Timms, Graham Henry; Williams, Andrew Caerwyn
Patent: US2004/122001 A1, 2004 ;
US 20040122001 A1
反应条件
1: 85 percent / BH3*THF / tetrahydrofuran / 2 h / 50 °C 2: 87 percent / DMSO; oxalyl chloride; triethylamine / CH2Cl2 / -60 - 20 °C 3: tetrahydrofuran / 2 h / -78 °C 4: 0.147 g / NaH / tetrahydrofuran; various solvent(s) / 1 h / Heating 5: 88 percent / Pd(OH)2/C; ammonium formate / ethanol / 2 h / 70 °C View Scheme
参考文献
Clark, Roger B.; Elbaum, Daniel
Tetrahedron, 2007 , vol. 63, # 14 p. 3057 - 3065
