反应条件
1.1: sulfuric acid / 20 h / Reflux 2.1: trifluoroacetic acid / 16 h / 22 - 80 °C 3.1: lithium hydroxide hydrate / tetrahydrofuran; ethanol; water / 16 h / 22 °C 3.2: Sonication 4.1: 1H-imidazole; 1,1'-carbonyldiimidazole / dichloromethane / 3 h / 22 °C 4.2: 16 h / 22 °C 5.1: polymer-supported trisamine resin / toluene / 40 h / 50 - 60 °C / Molecular sieve 5.2: 16 h / 22 °C View Scheme
参考文献
Ward, Richard A.; Brassington, Claire; Breeze, Alexander L.; Caputo, Alessandro; Critchlow, Susan; Davies, Gareth; Goodwin, Louise; Hassall, Giles; Greenwood, Ryan; Holdgate, Geoffrey A.; Mrosek, Michael; Norman, Richard A.; Pearson, Stuart; Tart, Jonathan; Tucker, Julie A.; Vogtherr, Martin; Whittaker, David; Wingfield, Jonathan; Winter, Jon; Hudson, Kevin
Journal of Medicinal Chemistry, 2012 , vol. 55, # 7 p. 3285 - 3306
