N-(5-溴吡啶-2-基)-2,2-二甲基丙酰胺合成路线 （共 8 条）
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane T=0 - 20°C;
参考文献
Zhou, Jun; Li, Bo; Hu, Fang; Shi, Bing-Feng
Organic Letters, 2013 , vol. 15, # 13 p. 3460 - 3463
反应条件
triethylamine in dichloromethane
参考文献
PFIZER INC.
Patent: EP842924 A1, 1998 ;
EP 0842924 A1
反应条件
1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / |Sealed tube 2: tetrahydroxydiboron / 0.17 h View Scheme
参考文献
Londregan, Allyn T.; Piotrowski, David W.; Xiao, Jun
Synlett, 2013 , vol. 24, # 20 art. no. ST-2013-S0695-L, p. 2695 - 2700
参考文献
Ross Kelly; Jagoe; Gu
Tetrahedron Letters, 1991 , vol. 32, # 34 p. 4263 - 4266
反应条件
1: [Cp*RhCl2]2; silver hexafluoroantimonate; copper diacetate / 1,2-dichloro-ethane / 24 h / 120 °C / |Schlenk technique; |Inert atmosphere 2: hydrogenchloride / methanol; water / 3 h / 60 °C View Scheme
参考文献
Zhou, Jun; Li, Bo; Hu, Fang; Shi, Bing-Feng
Organic Letters, 2013 , vol. 15, # 13 p. 3460 - 3463
反应条件
1: [Cp*RhCl2]2; silver hexafluoroantimonate; copper diacetate / 1,2-dichloro-ethane / 24 h / 120 °C / |Schlenk technique; |Inert atmosphere 2: hydrogenchloride / methanol; water / 3 h / 60 °C 3: NiII chloride hexahydrate; sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C 4: sodium hydride / mineral oil; tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
Zhou, Jun; Li, Bo; Hu, Fang; Shi, Bing-Feng
Organic Letters, 2013 , vol. 15, # 13 p. 3460 - 3463
反应条件
1: [Cp*RhCl2]2; silver hexafluoroantimonate; copper diacetate / 1,2-dichloro-ethane / 24 h / 120 °C / |Schlenk technique; |Inert atmosphere
2: hydrogenchloride / |Reflux
View Scheme
参考文献
Zhou, Jun; Li, Bo; Hu, Fang; Shi, Bing-Feng
Organic Letters, 2013 , vol. 15, # 13 p. 3460 - 3463
反应条件
1: [Cp*RhCl2]2; silver hexafluoroantimonate; copper diacetate / 1,2-dichloro-ethane / 24 h / 120 °C / |Schlenk technique; |Inert atmosphere
2: hydrogenchloride / methanol; water / 3 h / 60 °C
View Scheme
参考文献
Zhou, Jun; Li, Bo; Hu, Fang; Shi, Bing-Feng
Organic Letters, 2013 , vol. 15, # 13 p. 3460 - 3463
