2-氨基-6-甲基吡啶合成路线 （共 244 条）
参考文献
Feist; Kuklinski
Archiv der Pharmazie (Weinheim, Germany), 1936 , vol. 274, p. 425,435
反应条件
sodium amide; toluene
参考文献
Gezcy
Magyar Kemiai Folyoirat, 1956 , vol. 62, p. 162,164
Chem.Abstr., 1958 , p. 10075
参考文献
Feist; Kuklinski
Archiv der Pharmazie (Weinheim, Germany), 1936 , vol. 274, p. 425,435
反应条件
1: 25 g / Br2; AcONa; AcOH / 1 h / 15 °C 2: HNO3; H2SO4 / 0 - 60 °C View Scheme
参考文献
Yutilov; Svertilova; Minkina; Kirillova; Smolyar
Russian Journal of Applied Chemistry, 2005 , vol. 78, # 5 p. 787 - 790
参考文献
American Cyanamid Company
Patent: US6228869 B1, 2001 ;
US 6228869 B1
反应条件
1: 90 percent / ethanol / 16 h / Heating 2: 71 percent / diphenyl ether / 0.5 h / Heating View Scheme
参考文献
Singh, Ram; Geetanjali
Synthesis, 2005 , # 14 art. no. P04405SS, p. 2315 - 2320
反应条件
1: 97.9 percent / Et3N / CH2Cl2 / 18 h / Ambient temperature 2: 54.7 percent / aq. KMnO4 / 2 h / 75 °C 3: 88 percent / 10percent aq. NaOH / 2 h / Heating 4: 54.5 percent / HCl / 9 h / Heating 5: 100 percent / Et3N / CHCl3 / 5 h / Ambient temperature 6: 84.5 percent / DIBAL / toluene / 0.5 h / -70 °C 7: 83.8 percent / piperidine / benzene / 22 h / Heating 8: 99.5 percent / H2 / Pd / tetrahydrofuran; methanol / 5 h / 760 Torr / Ambient temperature 9: 50percent aq. NaOH / 2 h / Heating 10: benzene / 2 h / Heating 11: 96.6 percent / 50percent aq. AcOH / 0.5 h / Heating View Scheme
参考文献
Fukase, Koichi; Nakayama, Hideo; Kurosawa, Motohiro; Ikegaki, Toshiki; Kanoh, Takeshi; et al.
Journal of Carbohydrate Chemistry, 1994 , vol. 13, # 5 p. 715 - 736
反应条件
1: 100 percent / 1.5 h / 60 - 70 °C 2: 16.5 g / KMnO4 / H2O / 3 h / 75 °C 3: HCl / Heating View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; BAUMANN, Karlheinz; GOETSCHI, Erwin; GREEN, Luke; JOLIDON, Synese; KNUST, Henner; LIMBERG, Anja; LUEBBERS, Thomas; THOMAS, Andrew
Patent: WO2011/92272 A1, 2011 ;
WO 2011/092272 A1
反应条件
1: 82 percent / NaNO2, Br2, 48percent HBr / 5 °C 2: 43 percent / Cu, HMPA / 112 - 130 °C / autoclave 3: 21 percent / KMnO4 / H2O / Heating View Scheme
参考文献
Ashimori; Ono; Uchida; Ohtaki; Fukaya; Watanabe; Yokoyama
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 9 p. 2446 - 2458
反应条件
sulfuric acid; bromine in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; water
参考文献
Daewoo Electronics Co., Ltd.
Patent: US5691348 A1, 1997 ;
