2-氨基-6-甲基吡啶合成路线 （共 244 条）
反应条件
in ethanol 18 h; Heating;
参考文献
Elliott, Arthur J.; Guzik, Henry; Soler, Jose R.
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 1437 - 1440
反应条件
1: 65 percent / ethanol / 2 h / Heating 2: 62 percent / 61 percent nitric acid; conc. sulfuric acid / 5 h / 20 °C View Scheme
参考文献
Ikemoto, Tomomi; Wakimasu, Mitsuhiro
Heterocycles, 2001 , vol. 55, # 1 p. 99 - 108
反应条件
1.1: nitric acid; sulfuric acid / 12 h / 0 °C 1.2: pH 7 / Cooling with ice 2.1: water; sodium nitrite; sulfuric acid / 16 h / 0 °C 3.1: trichlorophosphate / 4 h / Reflux 4.1: sodium dichromate; sulfuric acid / 40 h / 30 °C View Scheme
参考文献
Beijing Yiling Bioengineering Co., Ltd.
Patent: EP2366691 A1, 2011 ;
反应条件
1: 82 percent / HBr, Br2, NaNO2, H2O / H2O / 1.) -25 deg C to room temp., 1 h 2: 80 percent / NaH / dimethylformamide / 100 °C 3: 80 percent / Br2 / ethanol / 0.5 h / 0 °C View Scheme
参考文献
Caprio, Vittorio; Mann, John
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 19 p. 3151 - 3155
反应条件
in toluene Substitution; Heating;
参考文献
Edmont, Dolores; Rocher, Richard; Plisson, Christophe; Chenault, Jacques
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 16 p. 1831 - 1834
参考文献
American Cyanamid Company
Patent: US6228869 B1, 2001 ;
US 6228869 B1
反应条件
1.1: 50 h / 150 °C 2.1: sodium hydroxide; water / 1 h / 20 - 120 °C 2.2: pH ~ 4 - ~ 5 / Cooling with ice 3.1: chlorosulfonic acid / dichloromethane / 2 h / 20 °C / Cooling with ice 3.2: pH ~ 6 - ~ 11 4.1: sodium tetrahydroborate; methanol / 1 h / 20 °C View Scheme
参考文献
AC IMMUNE S.A.; KROTH, Heiko; FROESTL, Wolfgang; PFEIFER, Andrea; MUHS, Andreas
Patent: WO2011/45383 A2, 2011 ;
反应条件
1: 64 percent / xylene / 2 h / Heating 2: 72 percent / CH2Cl2 / 1.) r.t., 1 h, 2.) reflux, 20 min 3: 84 percent / ethanol / 1 h / Heating 4: 68 percent / aq. KOH / Ambient temperature View Scheme
参考文献
Zupet; Tisler; Golic
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 7 p. 1731 - 1740
反应条件
PPA T=100°C; 1.25 h;
参考文献
Chandler, Christopher J.; Deady, Leslie W.; Reiss, James A.; Tzimos, Vasilios
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 1017 - 1019
反应条件
bromine; acetic acid
参考文献
Okafor,C.O.
Journal of Medicinal Chemistry, 1967 , vol. 10, p. 126
