2-氨基-6-甲基吡啶合成路线 （共 244 条）
反应条件
1: 100 percent / 1.5 h / 60 - 70 °C 2: 16.5 g / KMnO4 / H2O / 3 h / 75 °C 3: HCl / Heating 4: 25 percent / Br2 / CHCl3 5: 85 percent / 9M H2SO4, NaNO2 / H2O / 0.25 h / 0 °C View Scheme
参考文献
Kelly, T. Ross; Lang, Fengrui
Journal of Organic Chemistry, 1996 , vol. 61, # 14 p. 4623 - 4633
反应条件
1: in water 3 h; cooling; 2: With sulfuric acid; nitrobenzene T=110°C; Skraup synthesis; 0.5 h; 3: With sodium hydroxide in water pH=10; 1 h; cooling;
参考文献
Vu, Choua; Walker, DeeDee; Wells, Jason; Fox, Stephen
Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 4 p. 829 - 832
反应条件
1: 60 percent / polyphosphoric acid / 1.25 h / 100 °C 2: 75 percent / paraffin / 0.5 h / 350 °C 3: 92 percent / 2.5percent KOH, H2 / 5percent Pd on CaCO3 / methanol View Scheme
参考文献
Chandler, Christopher J.; Deady, Leslie W.; Reiss, James A.; Tzimos, Vasilios
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 1017 - 1019
反应条件
Acylation; 0.833333 h; microwave irradiation;
参考文献
Suri; Satti
Synthetic Communications, 2000 , vol. 30, # 20 p. 3709 - 3718
反应条件
in xylene 2 h; Heating;
参考文献
Zupet; Tisler; Golic
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 7 p. 1731 - 1740
参考文献
Allen; Van Allan
Journal of Organic Chemistry, 1948 , vol. 13, p. 603,605
反应条件
1: HBr; NaNO2 / -20 °C 2: CrO3 / H2SO4 3: H2SO4 View Scheme
参考文献
Ulrich, Gilles; Bedel, Sebastien; Picard, Claude; Tisnes, Pierre
Tetrahedron Letters, 2001 , vol. 42, # 35 p. 6113 - 6115
反应条件
1: 100 percent / 1.5 h / 60 - 70 °C 2: 16.5 g / KMnO4 / H2O / 3 h / 75 °C 3: HCl / Heating 4: 25 percent / Br2 / CHCl3 View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; BAUMANN, Karlheinz; GOETSCHI, Erwin; GREEN, Luke; JOLIDON, Synese; KNUST, Henner; LIMBERG, Anja; LUEBBERS, Thomas; THOMAS, Andrew
Patent: WO2011/92272 A1, 2011 ;
WO 2011/092272 A1
反应条件
1.1: 1.5 h / 90 °C 2.1: water; potassium permanganate / 4 h / 75 °C 2.2: pH 4 - 5 3.1: hydrogenchloride / methanol / 18 h / Reflux 4.1: bromine / chloroform / 40 h / 20 °C View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; BAUMANN, Karlheinz; FLOHR, Alexander; GOETSCHI, Erwin; GREEN, Luke; JOLIDON, Synese; KNUST, Henner; LIMBERG, Anja; LUEBBERS, Thomas; THOMAS, Andrew
Patent: WO2011/101304 A2, 2011 ;
WO 2011/101304 A2
反应条件
1: 82 percent / NaNO2, Br2, 48percent HBr / 5 °C 2: 43 percent / Cu, HMPA / 112 - 130 °C / autoclave View Scheme
参考文献
Ashimori; Ono; Uchida; Ohtaki; Fukaya; Watanabe; Yokoyama
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 9 p. 2446 - 2458
